- According to Dr Leonel Rojo, researcher at the Faculty of Chemistry and Biology, the use of Aristotelia Chilensis allows to reverse the problems caused by the use of psychotropic drugs, like obesity, diabetes and cardiovascular diseases.
Dr Leonel Rojo, researcher at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile, found that people using antipsychotic drugs for 6 continuous months exponentially developed obesity, insulin resistance, dyslipidemia and cardiovascular diseases.
According to the Chilean National Institute of Public Health, clozapine and olanzapine have been the most commonly imported psychotropic drugs in Chile in the past ten years for their low cost and effectiveness for the treatment of psychosis or schizophrenia in adult patients and the treatment of attention deficit disorder, autism, Asperger syndrome and bipolar disorders in children.
However, the side effects that they produce alerted Dr Rojo, as he found that antidiabetic drugs did not help patients to overcome their problem. He started looking for solutions, and after testing a Chilean product in laboratory, in 2012 he found an answer: Maqui berry (Aristotelia Chilensis), a small tree that grows in the center and the south of Chile.
“Descubrimos en Estados Unidos, que uno de sus compuestos es fuertemente antidiabético, así que pensamos que el maqui puede prevenir la obesidad que es causada por antisicóticos y descubrimos que previene la acumulación de lípidos en las células en pacientes tratados con estos fármacos”, explica el experto en toxicología.
“In the USA, we found that one of the maqui components is a strong antidiabetic compound, so we thought that maqui could prevent the obesity caused by antipsychotic drugs. We found that it reduces lipid accumulation in the cells of patients who are treated with these drugs,” Dr Rojo explains.
Research team
Dr Rojo has an extensive scientific experience. His work has been recognized by the New York Society of Cosmetic Chemists and the American Society of Pharmacognosy, after he discovered an anti-aging technology based on Pouteria Lucuma bioactive compounds.
The project has the collaboration of Dr Ilya Raskin, of Rutgers University, New Jersey (USA); a research team of Universidad de Chile, led by Dr Pablo Gaspar; and the Hadassah Academic College of Jerusalem.
The study is called “Evaluation of Anthocyanins from Maqui Berry in the Prevention of Clozapine-Induced Hepatic Lipid Accumulation, Activation of SREBP1c Target Genes and Obesity” and it is funded by a Fondecyt Initiation Project in the field of psychotropic drugs and metabolism.
Current situation and expectations
Currently, Dr Rojo and his collaborators continue working in the laboratory at the Faculty of Chemistry and Biology of Universidad de Santiago. At this stage, they are trying to elucidate how the natural maqui components (called anthocyanins) prevent lipid accumulation and the metabolic problem associated to the use of antipsychotics.
The researcher expects to conclude his work by the end of 2017 with a continuity project that allows using the product in patients. Dr Rojo says that this project will benefit the country, because he thinks that the product would not be expensive; and it would also be good for national economy, because people who collect and sell maqui are eager to find new uses for it.
Today, the product is considered as a super fruit and it is mainly commercialized in the United States. Besides, there are already companies interested in the project and in getting involved in it.
Translated by Marcela Contreras
