• The purpose of the study conducted by Juan Fernando Mejía Calle, who graduated from a M.A. program of Universidad de Santiago, is that companies are able to automatically identify features in sophisticated files that are not recognized by common antivirus software. In this way, it will possible to manage the problem step by step and take remedial actions to be better prepared in the future.

John opens a file in his computer at work, and, unintentionally, he ends up infecting all databases in his company. How can he determine whether that file is effectively malicious or not? Although some of these pieces of software can only be detected by antivirus software, malicious codes evolve continuously until they cannot be recognized, making difficult to avoid them.

In this context, a model that allows to automatically detect the features of a malicious software or malware and then follow steps to combat them, taking remedial actions, was the result of a study conducted by Juan Fernando Mejía Calle, who graduated from the M.A. program in Security, Forensics and Auditing of IT Processes of Universidad de Santiago de Chile. Mejía Calle is an Ecuadorian expert, holder of a scholarship of the Government of his country to study this program.

His work, “Modelo de proceso para análisis, caracterización y clasificación de archivos ejecutables potencialmente maliciosos en un entorno organizacional con sistema operativo Windows,” will be a contribution to both the companies affected by these attacks and the organizations in charge of cyber forensics.

The study suggests a process to capture malware evidence based on the features of different types of programs, providing information “that allows to know if the file got connected to another site, executed other programs or became self-executable or if it got encrypted,” Mejía explained. After that, the files analyzed can be classified as clean or malicious.

“According to what I have studied, there is not any standard model for this purpose. Each author suggests a pattern based on his/her experience,” Mejía says. To conduct this study, he reviewed literature on malware and registered the features that he considered relevant to define it.

The model that he presented showed an effectiveness of 92% using the cross-validation method.

Mejía says that cyber-attacks in Chile are increasingly sophisticated. “New malware attacks or zero-day attacks can infect a computer because they have not been recognized yet. This type of attack cannot be prevented, but it can be analyzed to take future remedial actions,” he says.

Translated by Marcela Contreras

• The research, led by Dr. Miguel Maldonado, professor at the Metallurgical Engineering Department, intends to optimize this process through new on-line air measurement equipment.

During the last couple of years, we have heard about a decline in copper production, and according to experts this is one of the reasons why the quality of the mineral has been reduced. One way to revert this situation is improving mining procedures, which is a priority for mining industry.

One of these processes is flotation, a method used to separate valuable minerals like copper from others. The process starts once the rock is ground and mixed with water to form a pulp. Some reagents that modify the mineral surface are added to this mixture. In this way, when bubbles of air are forced up through the pulp, they collide with particles and the ones containing copper, for example, go up to the surface making a froth rich in valuable mineral, ready to be removed.

This is the method studied by Dr. Miguel Maldonado, professor at the Metallurgical Engineering Department. “Although today improvements have been made to flotation process- by means of devices that measure the air flow forced into a flotation equipment or the use of cameras that continuously monitor de physical properties of the froth- we still do not have a full knowledge of how air dispersion in the bubbles affects the metallurgical performance of the process,” the researcher said.

This encouraged the academic to do a research project called “Estimating on-line air concentration in flotation systems,” funded by the Scientific and Technological Research Department (Dicyt) of Universidad de Santiago.

“We believe that this variable is important when determining the process performance, as it is related to the surface area available to collect the particles containing valuable mineral and, therefore, to the complete recovery of copper,” the researcher explained.

The researcher said that the project was born while he was doing his postdoctoral research in Canada, at McGill University, considered a pioneer institution in proposing ways of measuring this variable. At that time, while he was studying this technique, he found out a problem with the interpretation of Maxwell’s equation, which would lead to a measurement error.

For this reason, the academic decided to insist on seeking new techniques in order to solve the problem; this time, with a better knowledge of the system.

At the first stage of the research, essential aspects of the error made will be studied. For this purpose, experiments to get a better understanding of the Maxwell’s equation will be performed. McGill University will also take part in this research by sending a flotation column to support the study and by developing papers together about this topic.

At the second stage, new techniques will be explored to find a method that estimates the air concentration in real time, in order to control and optimize the process.

In the academic’s opinion, “the efficient recovery of valuable minerals like copper is very important, and this measurement method could provide significant information for optimizing the process. This will have all kinds of benefits, such as reducing the reagents added or reducing the water used. This fact is also important if we consider that in most mining operations the water resource is scarce.”

Translated by Marcela Contreras

• María Angélica Ganga, researcher at the Technological Faculty, leads a project to make technological improvements to the Pajarete wine fermentation in Huasco Valley. The project has been funded through the Innovation for Competitiveness Fund and has allowed improving the quality of this traditional product and recovering its original properties.

It is said that Jesuits brought the Pajarete wine to the north of Chile during the 17th century. This wine is characterized by its sweet flavor and it is produced mainly from black and muscatel grapes of the northern part of the country.

In the last few years, the Pajarete production has had a significant increase due to a development plan that has allowed local producers to commercialize it in better conditions, thanks to a strategy that allowed producing a first-quality product, including appellation of origin (geographical indications).

In this process, the Atacama Regional Government and the Association of Pajarete Producers of Huasco Valley have worked together with Universidad de Santiago in a project to make technological improvements to this wine fermentation process in order to improve its competitiveness.

The project- funded through the Innovation for Competitiveness Fund of the Atacama Region- has been led by María Angélica Ganga, PhD in Biological Sciences and a researcher at the Technological Faculty of Universidad de Santiago.

The researcher says that the project focused in strengthening the Pajarete production through the microbiological control of the vinification process and the selection and identification of native yeasts.

This is how a microbial strain collection was created and yeasts with technological potential for production were obtained. Besides, a standard methodology for their use was developed and handed to wine producers.

The researcher explains that Pajarete producers contacted the University and expressed their concern for having lost part of the properties of their wine in their attempt to industrialize their process and also for using yeasts different from the ones of the Atacama Region, what led to losing part of their “terroir” (the set of characteristics that describe and define a geographic region where grapes are grown).

“So, we worked to return the organoleptic properties to the product by using yeasts from that region. Now, the fact of recovering these properties allows the producers to keep the hallmark of a wine typical of that region; it is something of their own that is not reproducible in other regions,” she explains.

Anberta Debia, a Pajarete producer and member of the Association of Pajarete Producers, considers that the most important achievement of this project is that old people at Huasco Valley identified this new Pajarete with the one that was produced in this area decades ago.

“When we started working with industrial yeasts, people did not identify themselves with the product. Now we know that everybody thinks that the wine is more tasty, more aromatic and with a more fresh-raisin flavor. The grape is reflected in a much better way and that gives us a plus,” she says.

According to the producers, now that the quality production stage has been completed the following stage is to commercialize the product.

Their first objective is to get their product distributed in Santiago and the rest of the country and then, start exporting.

Opportunities for the industry

At present, Universidad de Santiago is implementing a new project with the purpose of developing a sustainable production system to provide Pajarete producers with the amount of yeast required for the their wine making.

At the same time, the University is applying for a third project to help producers to assure the innocuousness of the product, in order to become competitive, not only at a national level, but also at an international one.

Nibaldo Guaita, who is in charge of the Production Development Area of the Atacama Regional Government, describes the work done as very positive. He says that the problem with this wine was related to the fermentation process, which affected its quality. Now he bets that Pajarete will become a premium wine.

“We want to position Huasco Pajarete producers as a national example, with a high-quality wine that can compete with other sweet wines. This product already has the best level possible and this will help to reach a better market,” he says

Nibaldo Guaita said that they have taken the Pajarete wine to different international fairs and that it has awakened interest, but on these occasions, a new big challenge has arisen: to increase the volume of production.

Translated by Marcela Contreras
 

• “Entre biología y Utopía: Semblantes Ideológicos en las Ciencias de la Vida’ is the name of the Fondecyt Initiation project led by Dr Mauricio Espósito that will allow a synergy between biomedical research, communications and their future interactions. The study will last two years and it expects to prove the importance of the relations among different disciplines.

To analyze the historical and philosophical relation between biological knowledge and its multiple political, ideological and technocratic applications: that is the goal of the Fondecyt Initiation project led by Dr Maurizio Espósito. For this purpose, the academic at the Department of Philosophy of Universidad de Santiago will review some particular cases associated to sciences of life during the 20^th and the 21^st centuries, like the development of genomics in Latin America, for example.

Dr Espósito thinks that “it is very important to understand the philosophical and political implications of biomedical research beyond preconceived criticism, superficial exaltation of science or a merely abstract debate about what is right or wrong.”

According to him, some biological disciplines were formulated since ambitious scientific policies, which principles still cross with biotechnological utopias and contemporary ideologies.

“I think that many people speak about biotechnology or technology often criticizing or glorifying technological or scientific events without really understanding them. And understanding them does not only mean knowing the technical details unique to a discipline, but also having a definite idea about the controversies, interests, concepts, institutions and ambitions of the agents under the great umbrella that we call techno-science, that involves an interdisciplinary approach,” he says.

General guidelines

In this Fondecyt Initiation project, the academic expands his research line to address different national and Latin American cases. “I need to make clear that in this project, I am not interested in criticizing scientific events or proposing philosophical morals based on science-fiction fantasies. The project seeks to link up biotechnological research with the help of the history of science and the interdisciplinary tools given by the studies on science, technology and society,” he adds.

Among the possible options to spread the project information, Dr Espósito recognizes the value of the potential debate among the different disciplines of study and he adds that different activities will be organized, in which academics and the community in general will be able to participate, discuss and think about this issues.

Translated by Marcela Contreras

•    Using secondary sludge from industrial water treatment, researcher César Huiliñir, professor at the Department of Chemical Engineering, developed a new mathematical method for the biodrying process that proposes to reuse this sludge as biofuel. This technology proposal is supported by a Fondecyt Initiation Project.

After three years of work using secondary sludge from industrial water treatment, researcher César Huiliñir, professor at the Department of Chemical Engineering, developed a new mathematical model for the biodrying process that proposes to reuse these residues.

The proposal is one of the results of his Fondecyt Initiation Project (11121160), “Development of a new dynamic model for batch biodrying process of dewatered sewage sludge”.

According to the researcher, the sludge disposed of by industries has 80% of water, i.e., for every kilo of sewage sludge, an amount of 800 grams of water is lost. Besides, companies have to pay for removing this waste to prevent accumulation of residues and potential odours in their facilities. For this reason, finding an alternative solution may reduce costs.

“We bet that, if we reduce the amount of water of secondary sludge, it can be fed as fuel into boilers. That is why companies like paper mills can be benefited: if this works, it will allow them to reduce removal costs. We could use that sludge, burn it, and change it into a new type of biofuel, as it has already been done in Holland and Canada, where there are specific examples of mills that have implemented similar systems,” he said.

For this purpose, professor Huiliñir and his research team proposed a mathematical model- very easy to implement- that enable a more flexible system to better predict the moisture loss in the system. Up to now, there was not literature on this factor that could effectively enhance this operation.

Results of the study

Professor Huiliñir said that another contribution of this study was the background information they were able to collect on kinetics of volatile solid residues degradation. There was not any information about this in the literature of the area.

“With this (information), we will able to know how much energy is used in the process. The higher the solids consumption, the higher the energy released to dry the sludge. This will allow predicting behaviours and evaluating without having to experiment,” he said.

He could also analyze the amount of water and energy required to remove the water content through the different stages of this degradation process. “In the study, we built an experimental design in which we established how some conditions affect the dewatering operation and how much of energy that allows water evaporation comes from the chemical reaction in the process,” he added.

In order to develop this alternative model, they worked with sludge from paper mills. Now, they are working with water treatment sludge from a slaughterhouse and a meat packing plant.

Finally, professor Huiliñir highlighted the role played by undergraduate and graduate students, who were in charge of the laboratory work to test this model. “The students’ contribution was essential. Without them, we wouldn’t have been able to develop this project and get these results,” he concluded.

Translated by Marcela Contreras

• With a project that involves the use of ICTs in early teacher training, professors at the Department of Education Juan Silva and Paloma Miranda, won the first place in the international contest of the Education Sector Fund, in the "Digital Inclusion” Mode. 

Juan Silva and Paloma Miranda, both professors at the Department of Education, were awarded an international research grant by the Government of Uruguay for a project that involves the use of ICTs in early teacher training.

Professor Silva is Director of the Center for Research and Innovation in Education and ICT (CIIET, in Spanish) of Universidad de Santiago, and professor Miranda is Head of the Primary Education program at this same university.

The contest was organized by the National Agency for Research and Innovation of the National Commission for Innovation, Science and Technology (Conicyt, in Spanish) of Uruguay.

International contest

This was an international call for proposals and 34 projects were presented, but only 12 were selected for funding. The proposal of professors Silva and Miranda won the first place.

The team is made up of the two Chilean professors and Uruguayan and Spanish researchers and experts.

The project was designed to meet the need of developing digital skills, both to teach and to learn using ICTs, during early teacher training, so that future teachers are able to successfully include ICTs in their professional activities.

The development of these skills should be constantly evaluated to make improvements and promote institutional policies in this matter.

Objectives

The objective of the project is to compare the level of performance on digital skills - for teaching and learning- of final-year students at early teacher training programs in higher education institutions in Uruguay and Chile, and generate recommendations to enhance the inclusion of ICTs in this stage of training. The results will be shared with other countries of the region.

Particularly in Latin America, empirical studies on the subject are scarce. There is evidence of public policies for the inclusion of ICTs in early teacher training and examples of good practices, i.e., if policies and their orientations are defined, and what the institutions are doing in this regard.

Besides, there are proposals for models and standards and studies on how students perceive the inclusion of ICTs in early teacher training, considering the technology available, the use of technologies by students and teachers, among others.

However, in spite of the above, there is not any study that reports on the level of performance on digital skills of students at teacher training programs. 

(Photo)

The project involves the use of ICTs in early teacher training

Translated by Marcela Contreras

• Dr Bernardo Morales Muñoz, director of the Laboratory of Neuroscience of Universidad de Santiago, is leading a project that seeks to reverse the effects of this type of disorder and enhance the memory and learning process. The chemical derives from the alkaloid sauroine synthesized by Huperzia saururus and it would allow to combat disorders like Parkinson’s disease and Huntington’s disease.

Neurodegenerative diseases are characterized by cellular aging and neuronal death. This has led scientists to study different possibilities to reverse or reduce their effects on patients. One of these studies is being conducted at the Laboratory of Neuroscience of Universidad de Santiago de Chile, as Dr Bernardo Morales Muñoz explains.

A research group is working on a chemical compound that helps to enhance the memory and learning process, which therapeutic use would reverse the effects of neurodegenerative diseases. “For example, in the case of Alzheimer’s, when there are little neurons left, this compound could activate them and counteract the memory loss,” Dr Morales says.

The compound is derived from sauroine, an alkaloid synthesized by Huperzia saururus, a plant popularly known as cola de quirquincho that grows in the Andes, in Argentina. Its benefits could be applied to other disorders like Parkinson’s disease and Huntington’s disease.

Side effects and environmental considerations

The study is part of a joint project with Universidad Nacional de Córdoba, Argentina, where they started modifying the compound chemically. “In Argentina, an excellent research group chose us to continue with the following research stage because we have specialized in memory and learning,” he says.

One of the main problems in the process to develop drugs is that large amounts of raw material are required, having an impact on the environment. “The idea is to isolate the compounds, understand them and be able to modify them chemically in order to enhance their effects. Then, we should be able to synthesize them, leaving behind the environmental concerns.”

Another aspect that should be considered is that people prefer more natural drugs, because they think that artificial drugs can have more serious side effects in comparison to drugs derived from natural compounds.

National and international patents

In Chile, Universidad de Santiago de Chile has already filed a patent request to protect the rights and future commercialization of the product. “We pretend to file patent requests abroad too, particularly in England, where some companies have shown interest in the project,” Dr Morales explains.

Although Dr Morales recognizes that more tests are required, the study has progressed well. “There are mouse models of Alzheimer, so the next step is to test the compound in them,” and then, the compound will be tested in human beings. The researchers think that they will produce an oral drug, as it would be more comfortable to use.

Translated by Marcela Contreras

• Dr. Claudio Vasquez investigates the resistance of microorganisms in the Antarctic to tellurite, a derivative of metallic tellurium, which is very harmful and toxic to the environment.

Tellurium is a very scarce element in the earth's crust and its biological role is unknown to date. Although in its elemental state (Te ° metallic tellurium) it exhibits no toxicity, some of its derivatives, such as tellurite, are highly damaging to most bacteria.

In this context, Dr. Claudio Vasquez, professor at the Faculty of Chemistry and Biology at the U. of Santiago will be in charge of the Fondecyt project: "Antarctic tellurite-resistant bacteria: new mechanisms of resistance",  for three years.

The academic works with bacteria isolated in Antarctica, in order to analyze how the microorganisms react in a cold context in contact with the toxic. For the research, 800 toxic- resistant microorganisms, coming from 100 different Antarctic samples, were isolated. "Of all the samples, we chose four which showed greater resistance to unveil the defense mechanisms they use," the researcher says.

Dr. Vasquez adds that "over the years, we have identified proteins that help the cell to remove this toxic and, therefore, we think that these bacteria that have received more stress by being in extreme conditions at the Antarctic, could exhibit more sophisticated mechanisms. Our goal is to find new genes that encode novel proteins involved in the defense against these toxics.” the expert says.

As a projection of this study, the introduction of new genes into plants that grow in tellurium- contaminated environments, such as some mining areas, is expected. This would help the plants so that they can eliminate the polluting elements.

Pollution

The tellurite, produced as a result of industrial pollution, drains in groundwater by inhibiting or eliminating microorganisms that might be beneficial. It affects bacteria, fungi, plants and animals. For this reason, it is important to control the discharges which come from industrial exudates containing tellurium.

Tellurium is the molecular basis of solar cells that collect energy; therefore, any accident that might happen with these solar panels could release toxic elements.

• Researchers at the Food Science and Technology Research Center of Universidad de Santiago de Chile (CECTA- USACH, its acronym in Spanish) will participate in a Fondef project that seeks to improve enzymes’ ability to produce lactose-free milk in cold conditions, increasing the efficacy of the dairy products industry. In partnership with members of the Chilean Antarctic Institute (INACH, its acronym in Spanish), they will search for enzymes in different microorganisms from the Antarctica that would allow working at low temperatures. In Chile, 60% of the population suffers from lactose intolerance.

 

Lactose intolerance is a condition that affects millions of people all over the world. It is estimated that 30 to 50 million people in the United States suffer, to some degree, from this condition. An estimated 90% of the Asian population has the same problem, just like 60% of the Chilean population.

Lactose is a type of sugar found in milk and other dairy products. The body needs an enzyme called lactase to break down lactose. Lactose intolerance occurs when the small intestine cannot produce enough lactase. This is the reason why lactose content in milk has to be reduced, so that people suffering from this condition are able to drink it.

The project expects to detect an enzyme that allows breaking down lactose at low temperatures and at a better level of efficiency than the one of the enzyme currently used in the industry. Researchers will search for this enzyme in different microorganisms (fungi, yeasts and bacteria) that have been already isolated and brought from the Antarctic continent.

Once the efficacy at low temperatures of this “Antarctic enzyme” is described and tested, the project will be able to move forward to obtain the resources required for creating the conditions to transfer this biotechnological product to the industry.

In this way, finding enzymes which are highly effective in reducing the lactose content of milk at low temperatures will not only allow to optimize some of the current production processes, but it will also open new possibilities for the design of lactose-content reducing processes in cold conditions and for the production of lactose-free foods.

The project called “Antarctic enzyme with highly effective β-galactosidase activity to reduce lactose content of milk at low temperatures” (ID14I10098) will last for two years and will be funded by Fondef and Universidad de Santiago. It will be led by Dr Renato Chávez Rosales (Director), professor at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile, and Dr José Luis Palacios Pino (Alternate Director), researcher at Cecta-Usach.

The experts will work in partnership with members of the Chilean Antarctic Institute in the search for the enzyme in different microorganisms brought from the Antarctica.

Translated by Marcela Contreras

• “Universidad de Santiago has all the potential to be number one in most areas (of research in the country),” Dr Pablo Zamora, Scientific Director of University of California Davis in Chile, says. The institution opened its centre in Santiago last April, thanks to the CORFO’s Program Attraction of International Centres of Excellence. He adds that his institution is interested in the possibilities of research and development in biology, chemistry and agricultural management, among others.

Dr Pablo Zamora, graduate of the Faculty of Chemistry and Biology of Universidad de Santiago and current Scientific Director of University of California Davis in Chile, proposes a research model based on demand. Last April, this institution established a research centre in Chile thanks to the CORFO’s Program Attraction of International Centres of Excellence.

On April 21^st, President Michelle Bachelet opened the UC Davis-Chile Life Sciences Innovation Centre in Santiago, Chile, a worldwide example in the development of research and solutions in agriculture, forestry and life sciences.

The founding academic partners are Universidad de Tarapacá, Universidad de Talca and Universidad Andrés Bello, while the corporate partners are Viña Concha y Toro and Viña San Pedro-Tarapacá. Currently, Universidad de Santiago de Chile is in the process of ratifying its incorporation to UC Davis Chile.

Dr Pablo Zamora, graduate of the Faculty of Chemistry and Biology of Universidad de Santiago and PhD in Biotechnology, leads the scientific area of this initiative and is in charge of facing this new challenge of doing science form a perspective that strengthens the links between the corporate and the academic worlds.

Interest

“We are interested in Universidad de Santiago for its research and development capabilities in biology, chemistry, agriculture and agriculture management in the Technological Faculty. Another big advantage is the capability that the University has in engineering issues,” Dr Zamora says.

Universidad de Santiago will be represented by Dr Alejandra Moenne, professor at the Department of Biology of the Faculty. She will be the technical counterpart in the Scientific Board of US Davis Chile. She will be in charge of leading research proposals and representing the University in the projects managed in partnership by both institutions.

“We see Universidad de Santiago in different roles. For example, in the area of applied research, with its laboratories and also in development issues,” he says.

“The UC Davis Chile research model is different, but not original. It is based on the demand. In Chile, this has not been well developed because companies have little capacity to generate research. There is also a sort of dissociation between the companies’ challenges and the research conducted by universities,” he explains.

UC Davis Chile focuses its work on four large areas: wine making, post harvest and climate change technologies and genetic improvement.

“In order to make sure that research projects will really have an impact on industry, we will meet with companies, learn about their problems and analyze the knowledge and services offered by UC Davis and its national academic partners to formulate projects to solve those problems. This seems quite obvious, but it usually does not occur,” he says, regarding the way in which UC Davis Chile works.

“Not all companies consider scientific research as a tool that can make them more productive. UC Davis has a large experience in collaborating and generating solutions for the production problems that companies have. This allows them to start seeing research as a means to enable increased competitiveness,” he adds.

Back in Chile and at the University

For this graduate of the Faculty of Chemistry and Biology and current member of the staff of the doctoral program in biotechnology, collaborating with the University is not only a matter of being fond of the University; he thinks that Universidad de Santiago “has all the potential to be number one in most areas (of research) in Chile.”

“Being back at the Faculty is very gratifying. Its progress is evident and, for this reason, I have full confidence that Universidad de Santiago can be number one at a national level,” he says.

Ministry of Science

With regards to President’s Bachelet announcement of the creation of a Ministry of Science, Dr Zamora says: “It is valuable, because, in some way, it makes science visible, but it does not guarantee the development of better science in Chile. As a scientist, I think it is valuable, but I believe that there should be a focal point and clear guidelines, and because we are a country with little resources, some strategic areas should be clustered together and strengthened,” he says.

“I think that the State should make an effort in involving and building links with the productive sector. In turn, the private sector should commit itself to allocate more resources for research and development. UC Davis in Chile will contribute to strengthen the relation science-industry, together with other institutions. Is this happening? Yes, it is. Are we on the right track? I believe we are. Is all this happening at the speed the country requires? I think it is not, but things don’t happen from one day to the next,” he concludes.

Translated by Marcela Contreras