• The work of the CESS Oxford-U de Santiago was evaluated by the Newton-Picarte Fund as one of the best projects.

The funding allocated by this program of the British Government will allow the Center to continue its path to become a hub of experimental research in Social Sciences in Latin America. It will allow promoting the training of PhD students and professors in experimental research, particularly in experimental methods for the analysis of public policies.

The Newton-Picarte Fund program is a partnership between the Chilean’s National Commission for Scientific and Technological Research (Conicyt, in Spanish) and the British Government to support scientific research in Chile, particularly in joint research projects involving Chilean and British scientists, technology transfer and innovation, advanced human capital development for research and innovation, and the generation of  challenges that provide innovative solutions for the development of our country. 

Funding allocation

Raymond Duch, Director of the Center for Experimental Social Sciences Oxford-Universidad de Santiago, explains that the most important contribution of this fund is that it will allow providing training to policy makers in Chile.

“This training will help them to apply experimental methods to design more effective and efficient policies in different areas. First, we will focus on Education, but in the long term, we will include other important areas of Chilean politics,” he emphasizes. Besides, the fund awarded will finance a workshop with renowned social scientists worldwide.

“It will be a unique opportunity for students in Chile to meet with policy makers and analysts and discuss the current policies faced by the Chilean Government and also give ideas on how to make policies that meet their goals. For example, a way of improving job opportunities for Chilean youngsters who have problems to enter the labor market,” he says.

The Newton-Picarte Fund will allow the Center to offer its training programs, research and educational possibilities to a wide variety of Chilean academics, the Government and the private sector.

“The training courses that we have developed for our partners in the Chilean Government will be available for ministries, students and teachers as well as decision-makers in the private sector,” Director Duch concludes.

The funds were awarded after a highly competitive process in which the CESS Oxford-U de Santiago was among the best evaluated projects.

Translated by Marcela Contreras

• A study by Dr. Mario Tello, researcher at this center, establishes a previously unknown relationship between an infectious salmon anemia (ISA) genome segment and its virulence.

The study by this researcher at the Aquaculture Biotechnology Center and the Faculty of Chemistry and Biology, University of Santiago de Chile, could provide important insights about how to predict salmon mortality by the ISA virus, a disease that affects Chilean aquaculture since 2007.

The research "Analysis of the use of codon pairs in the HE gene of the ISA virus shows a correlation between HPR bias in codon pair use and mortality rates caused by the virus" was published in the June issue of the Virology Journal, a specialized international publication.

The journal provides details of the investigation conducted by the University Of Santiago de Chile’s scientist who was able to identify the role and the relationship of a segment of the ISA virus by using bioinformatics tools and the existing literature.

According to Dr.Tello, the results of this study are one of the first hypotheses to explain why a highly variable region of the virus, called HPR (High Polymorphism Region), would be associated with the observed virulence.

 "Our results suggest that there is a region of the virus affecting its transmission and its ability to cause the disease. “That is to say, our analyzes suggest that there is a direct relationship between the mortality caused by the virus and the efficiency of its translation", Dr. Tello says.

According to the researcher, "the strain of the virus found in Chile would be one of the most efficient in the translation, and this would be directly related to an increasing mortality," and explain one of the possible reasons for the high mortality reported in our country.

Although the in vitro results have not been confirmed yet, the research is already an important step in deciphering the ISA virus characteristics, and it could provide solutions to the salmon industry. "Perfectly, these solutions could aim at generating a virulence predictor based on the analysis of the HPR region, a predictor in which we are working," the scientist says.

• Dr. María José Galotto, director of Universidad de Santiago’s Packaging Laboratory, was appointed as the National Contact Point for Horizon 2020 Framework Program in the area of nanotechnology. Horizon 2020 is a European program that provides funding for research and innovation in different fields. “This is in recognition of the University’s positioning in the area of Nanoscience and Nanotechnology, reached through CEDENNA,” the researcher said.

The National Commission for Scientific and Technological Research (Conicyt, in Spanish) informed that Dr. María José Galotto, director of Universidad de Santiago’s Packaging Laboratory (Laben, in Spanish) was appointed National Contact Point for the Horizon 2020 Framework Program in the area of “Nanotechnologies, Advanced Materials and Advanced Manufacturing and Processing.”

Dr. Galotto said that her appointment “is in recognition of the University’s positioning in the area of Nanoscience and Nanotechnology, reached through the Center for the Development of Nanoscience and Nanotechnology (CEDENNA, in Spanish), where nanotechnology is being applied to different areas of knowledge. This appointment will consolidate this new line of research and this positioning.”

According to Dr. Galotto, it is also in recognition of the constant work that Laben has developed over time, which results have been reflected in several research projects, publications in ISI journals and patents. This, in turn, results in a very close relation with the food and agricultural industry and food packaging industry at a national and international level.

The Laben was invited to be part of the International Association of Packaging Research Institutes (IAPRI). This membership, awarded by invitation only, is proof of the international recognition that our University has received.

Dr. Galotto’s appointment is also important because this area has a great future in the Food Science and Technology field; therefore, being able to get in contact with other research groups in Chile and abroad, will strengthen the links between the University’s academics and other researchers.

Among her new responsibilities, she will have to promote and foster the participation of nanotechnology research groups in the Horizon 2020 Framework Program, in which Chile will be entitled the same benefits that the European Union member states enjoy.

Regarding this, Dr. Galotto said that “up to date, we have had the first work meeting at Conicyt and we have scheduled others for the second semester, both here in Chile and in Europe.”

Nanotechnology

According to the researcher, “nanotechnology will integrate with food and agricultural industry as an option for developing food with better sensory and nutritional properties, better quality, and useful life, and greater safety.”

Dr. Galotto specified that our University is well ahead in this area, since the Laben has been working several years in applying nanotechnology to food packaging.

She added that researchers at Laben have led studies, in which nanotechnology has been applied, for example, to the development of packaging with anti-microbial activity to extend the life of food like salmon, or to reducing the level of compounds that accelerate the ripening of climacteric fruits like kiwi or avocado, among others.

Translated by Marcela Contreras

• Researchers at the Food Science and Technology Research Center of Universidad de Santiago de Chile (CECTA- USACH, its acronym in Spanish) will participate in a Fondef project that seeks to improve enzymes’ ability to produce lactose-free milk in cold conditions, increasing the efficacy of the dairy products industry. In partnership with members of the Chilean Antarctic Institute (INACH, its acronym in Spanish), they will search for enzymes in different microorganisms from the Antarctica that would allow working at low temperatures. In Chile, 60% of the population suffers from lactose intolerance.

 

Lactose intolerance is a condition that affects millions of people all over the world. It is estimated that 30 to 50 million people in the United States suffer, to some degree, from this condition. An estimated 90% of the Asian population has the same problem, just like 60% of the Chilean population.

Lactose is a type of sugar found in milk and other dairy products. The body needs an enzyme called lactase to break down lactose. Lactose intolerance occurs when the small intestine cannot produce enough lactase. This is the reason why lactose content in milk has to be reduced, so that people suffering from this condition are able to drink it.

The project expects to detect an enzyme that allows breaking down lactose at low temperatures and at a better level of efficiency than the one of the enzyme currently used in the industry. Researchers will search for this enzyme in different microorganisms (fungi, yeasts and bacteria) that have been already isolated and brought from the Antarctic continent.

Once the efficacy at low temperatures of this “Antarctic enzyme” is described and tested, the project will be able to move forward to obtain the resources required for creating the conditions to transfer this biotechnological product to the industry.

In this way, finding enzymes which are highly effective in reducing the lactose content of milk at low temperatures will not only allow to optimize some of the current production processes, but it will also open new possibilities for the design of lactose-content reducing processes in cold conditions and for the production of lactose-free foods.

The project called “Antarctic enzyme with highly effective β-galactosidase activity to reduce lactose content of milk at low temperatures” (ID14I10098) will last for two years and will be funded by Fondef and Universidad de Santiago. It will be led by Dr Renato Chávez Rosales (Director), professor at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile, and Dr José Luis Palacios Pino (Alternate Director), researcher at Cecta-Usach.

The experts will work in partnership with members of the Chilean Antarctic Institute in the search for the enzyme in different microorganisms brought from the Antarctica.

Translated by Marcela Contreras

• Plastic containers have caused an out-of-proportion environmental crisis all over the world. In this regard, Dr Alejandra Torres, professor at the Food Science and Technology Research Center is developing new containers with lower environmental impact through the Fondecyt Initiation Project (11140404,) “En la impregnación supercrítica de compuestos naturales en biopolímeros utilizados como envases de alimentos.”

The purpose of the study led by Dr Alejandra Torres is to inquire about new elements to produce new containers with lower environmental impact, by enhancing their properties through a novel process that involves the incorporation of substances that reverse the microbiological damage. Dr Torres is a professor at the Food Science and Technology Research Center (Cecta, in Spanish) and is member of the solid research team of the Packaging Laboratory of Universidad de Santiago (Laben, in Spanish).

The study was funded by the Fondecyt Initiation Project (11140404), ‘En la impregnación supercrítica de compuestos naturales en biopolímeros utilizados como envases de alimentos’.

According to the expert, through this initiative they will try to improve the production of food containers in three different areas: environment, new properties and new attributes.

The project addresses three essential aspects of research and development of new food packaging: the use of vegetal antimicrobial active compounds, the process to incorporate theses substances into the plastic material, and the material used to produce containers.

Currently, most of the plastic packaging used for food is made from petroleum-based raw materials. This causes a huge environmental impact for the plastic waste build-up.

“In the project, we will work with a biodegradable plastic material called polylactic acid, which is derived from renewable resources, such as corn. However, this type of material has some disadvantages. For example, it is highly permeable to water vapour, reducing the shelf life of products and/or increasing the risk of food-transmitted diseases,” Dr Torres says.

Incorporation of natural substances

A second important aspect addressed in this project is the incorporation of natural substances into packaging. These compounds come from essential oil extracts based on herbs, like oregano and thyme. They have antioxidant and/or antimicrobial properties that could extend the shelf life of the packed product and could keep its quality.

There are several ways of incorporating these substances into plastic containers. “One of the most common processes in food industry is the extrusion process. However, it usually requires high temperatures, resulting in the loss of the properties of the substances in the natural compounds,” the researcher says.

For this reason, this project intends to use the supercritical impregnation process as incorporation method.

This method has long been used in the field of medicine and one of its main advantages is that it does not require high temperatures, preventing the thermal degradation of the natural substances and, consequently, the degradation of its activity.

Regarding the expectations for this study, Dr Torres says that the results that they have obtained up to know are very interesting and promising for the development of new food packaging using more eco friendly materials.

Translated by Marcela Contreras

• At the “Variabilidad Hidrológica en la Determinación del Caudal Ecológico” seminar held at Universidad de Santiago, Dr Matías Peredo presented a new model that allows small hydroelectric power plants to have a constant flow of river water.

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During the “Variabilidad Hidrológica en la Determinación del Caudal Ecológico” seminar held at Universidad de Santiago, Dr Matías Peredo, professor at the Department of Civil Engineering in Civil Works, presented a new model that allows small hydroelectric power plants to have a constant flow of river water.

The method simulates a physical habitat that includes fish and also leisure time activities, like sport fishing. The purpose of this model is to provide a way of measuring how much water these small power plants require to keep constantly operating, without damaging the ecosystem and independently of rain shortages.

Current Chilean regulations establish that there always should be a specific water flow limit to preserve river ecosystems. However, Dr Peredo says that, just like flora and fauna vary according to dry and rainy years, water flow should change to preserve that ecosystem.

“If more water runs, the volume of water should be higher; and if less water runs, then the volume should be lower. What should not happen is to always keep the minimum volume of water stated by the national regulations, as this not sustainable,” he says.

He adds that the purpose of the model developed is to allow the possibility of bringing more water to generate hydroelectric power by means of variations in the ecologic water volume, and at the same time, to protect the ecosystem. “This is the reason why this is a sustainable energy development.”

The study results could propose more diverse ways of hydroelectric power generation, promoting the incorporation of small power plants.

“The goal is not to rely only on large power plants, but also on small plants, as they could contribute to meet energy demands during dry seasons,” he explains.

The study allowed to conclude that rivers naturally change their flows, as they are flexible. This is why in dry years, water volume should be reduced: to have a delta of water that could be used by small power plants.

For his part, Dr Juan Manuel Zolezzi, President of Universidad de Santiago de Chile highlights the importance of this study and the support that our university “gives to this type of initiative, through which professors can strengthen their academic and scientific networks to build knowledge at the service of our country.”

He said that the seminar “allowed to reflect on how to transfer the results and new knowledge to environmental assessment agencies and the market through training activities, seminars, conferences and the development of written material, among others.”

In this project, Dr Peredo worked in partnership with the Environmental Assessment Service (Servicio de Evaluación Ambiental, SEA), that requested and validated this work, and the Chilean Economic Development Agency (CORFO, in Spanish), that funded the project through a public goods for competitiveness contest.

The Department of Civil Engineering in Civil Works of this university, together with a multidisciplinary team of 25 professionals including hydrologists, geographers, biologists and experts in rural development and environmental engineers, worked at this project.

Translated by Marcela Contreras

•     Physical Review Letters (PRL) will publish an article about this important development in the control of chemical reactions using quantum optics. In simple terms, Dr Herrera, researcher at Universidad de Santiago, explains that they proved that these reactions or electron transfers can be accelerated or reduced.

At the end of the month, the renowned American journal of Physics, Physical Review Letters (PRL) of the American Physical Society (APS), will publish an important discovery in this field made by Dr Felipe Herrera, professor at the Department of Physics of Universidad de Santiago de Chile, and Dr Francis C. Spano, professor at Temple University in Philadelphia, USA.

The article (“Cavity-controlled chemistry in molecular ensembles”) will highlight the development made by these researchers in the control of chemical reactions by means of quantum physics. In simple terms, Dr Herrera explains that they proved that these reactions or electron transfers can be accelerated or reduced.

Graphically, the model consists of an optical cavity surrounded by two mirrors that do not allow light to go through, “so the amount of energy is the minimum possible in an electromagnetic field. That is to say, there is cero or one unit of light energy, which is also called photon,” Dr Herrera explains.

Dr Herrera remembers that, at a first stage, they asked themselves about “the effects that the optical cavity could have on chemical reactions or electron transfers: if the cavity would accelerate them, suppress them or if nothing would happen at all.”

In this context, the researcher says that they finally “found a mechanism through which this quantum optical cavity can dramatically accelerate the reaction and electron transfer in molecules.”

The basics

With regards to this theoretical discovery, Dr Herrera explains the process: “First, there are two players: the electron that is going to be transferred and the vibration of the molecules that, in a way, affect how this electron is going to be transferred from one place to another. If there is too much vibration, the electron will be disturbed and the transfer will be inefficient.”

“When you add another factor, like the optical cavity, there is a third player: the photon, which will now interact with the electron inside the cavity,” he says.  

“We discovered that quantized light plays a game in which the electron becomes a photon and the photon turns again into an electron and vice versa. The game only occurs inside the cavity and it makes the electron to stop interacting with the vibration, eliminating or blocking vibrations,” he explains. 

With regard to what material inside the cavity accelerates or reduces the electron transfer, Dr Herrera says that they have tested organic materials or organic molecules, like the ones that form the human body. “This organic material could also be a protein, according to the experiments conducted by other researchers that have based their studies on our discovery,” he adds.

Physical Review Letters

The article about this development was first published in the online edition of Physical Review Letters and, at the end of June, it will be published in the print edition. Dr Herrera says this is a great honor for them, as this journal is the most prestigious one in the field of Physics.

Translated by Marcela Contreras

• Inspired by the Fukushima nuclear disaster, academics from the U. of Santiago are developing a model, based on a mathematical theory that defines in minutes an action plan to deal with disasters. They published a paper about this research in the indexed journal "International Journal of Computers, Communications & Control."

It has been two years since the earthquake in Japan happened. This catastrophe caused more than 15,000 deaths and the most important nuclear disaster of the 21st century: the Fukushima Nuclear Plant explosion. This disaster demonstrated the great amount of time required to determine an action plan to cope with these events and the consequent risk for human lives.

This kind of situations led researchers from our University to find a model that could improve these response times. The project manager is Oscar Vasquez, industrial engineer graduated in this University; he has a Master’s degree, from the Ecole Polytechnique in Paris, and currently he is a  Ph.D. candidate at the Université Pierre et Marie Curie, Paris VI. He works with Dr. Juan Sepúlveda, director of the Department of Industrial Engineering, and the academics Miguel Alfaro and Luis Valenzuela-Osorio. Together, they published a paper about this research in the indexed journal "International Journal of Computers, Communications & Control."

The title of the paper written by the research team, composed of industrial and electrical engineers, was "Disaster response project planning: a resolution method based on a theoretical model of games.” The research was published in April by the specialized journal.

Vasquez says the method is a good and fast solution to the problem of assigning activities among a number of available resources in disaster environments. Based on the mathematical theory of “game", they seek to deal with computer applications that are currently used to solve these situations. This is achieved by finding the balance point as part of a theoretical game where activities and resources are the players.

The researcher adds: "Getting a good answer just in seconds is a key issue in disaster situations, considering that the computational complexity of the problem might involve obtaining the optimal solution in hours or even days, a period of time in which the increasing disaster might cause the loss of human lives and infrastructure."

The results of the proposed model showed a difference of 15 percent in relation to the optimal solution, but less than 1 percent in relation to the time required by last generation software. "The idea behind this kind of environment is to save as many lives as possible, and this is achieved if  less time is used in order to give a good answer to the problem”, the specialist says.

Currently, the team is improving the resolution method, defining new subroutines and starting players. Preliminary results have shown a reduction of the gap between their results and the optimal solution, with a difference of only 9 percent.

By Lorena Jimenez
 

• Yeast is a type of fungus that is present in multiple fermentation processes required for food. Due to this fact, new applications of yeast are being studied to decontaminate what we eat in a natural way and at low costs. The study is being conducted in the context of an Initiation Fondecyt project led by Dr Francisco Cubillos Riffo, a researcher at the Food Science and Technology Research Center of Universidad de Santiago.
  
   
  
  Yeast plays an essential role in the making of liquors, beer and bread. This fungus allows multiple fermentation processes required for producing foods as we know them. However, the importance of this catalyst goes beyond food production: it has the characteristic of controlling some mycotoxins. Mycotoxins are natural food contaminants that can cause acute poisoning when ingested, inhaled or absorbed.
  
  Through a genetic analysis of the response to the interaction between natural contaminants and yeast, the study led by Dr Francisco Cubillos Riffo seeks to develop new applications that allow decontaminating foods in a natural way and at low costs. 
  
  According to professor Cubillos, food innocuousness is very important in Chile, both for imports and exports. “The laboratory of Food Science and Technology Research Center of Universidad de Santiago (CECTA) is focused on research on food innocuousness. The type of yeast that we are studying now has the characteristic of decontaminating mycotoxin-containing foods,” he added.
  
  Preventing diseases
  
  The importance of this study lies on the need for preventing diseases transmitted by animals, eliminating contamination of human-consumption products. The analysis of this strain and others coming from different places in the country seems to be suitable to find effective applications.
  
  “We will study yeasts of different origins and then we will evaluate them at a genetic level. We will be able to determine what yeast is the one with the highest ability to degrade pollutants or decontaminate food, and at the same time, will conduct genetic studies on the different strains collected,” Dr Cubillos said.
  
  “Many of these toxins manage to enter the food chain and cause damage; therefore, it is necessary to find natural alternatives for decontamination. Yeast is not a chemical product, it is not a toxic treatment, it is cheaper, and most of the time, it is completely innocuous,” he added.
  
  The study will have a broad impact and Dr Cubillos considers the new possibilities as favorable. “Eventually, we could reach the industry and start partnerships with the Faculty of Administration and Economics. Also, with the data collected during the project, mathematical models can be developed to determine the specific behavior of yeasts in stressful environments, what would contribute even more to future studies,” he said.
  
  Translated by Marcela Contreras

• Dr Manuel Azócar, professor at the Department of Chemistry of Materials of Universidad de Santiago was recognized as the best scientific publication reviewer in the Material Science Engineering C international journal. The expert is also a reviewer in other six different journals in this field in the United States, Asia, Europe and Latin America.

Dr Manuel Azócar, professor at the Department of Chemistry of Materials of Universidad de Santiago was recognized as the best scientific publication reviewer in the Material Science Engineering C international journal, for reviewing around 30 papers in one year.

He is also a reviewer for other six journals in the field for which he usually evaluates the standard: an average of 5 article submissions. However, for the journal that recognized him, he evaluated an outstanding number of papers, so it demanded a very intense work. He expressed his gratitude for this recognition and said that he has reviewed works from the United States, Asia, Europe and Latin America.

Dr Azócar has also published in the Material Science Engineering C journal since 2014 before becoming a reviewer.

He became a reviewer on his own merit, studying materials with potential medical applications, specifically metals like copper and silver, which have antibacterial properties to combat bacteria, viruses and fungi, among other microorganisms.

All the articles undergo an expert “blind review”. This means that the author does not know who is evaluating his/her article. The committee is made up of two reviewers and they decide if the article is accepted or not. If there is a tie, they may call for a third opinion.

Dr Azócar says that the process for the approval of scientific publications is very rigorous. “I rejected 60% of the articles. This usually happens, because in science, the standards to accept articles are very strict. Most of the article submissions are usually rejected for writing problems, poor contributions, and poor quality and lack of novelty,” he explains.

Scientific connectivity

The Materials Science and Engineering C: Materials for Biological Applications journal can be digitally accessed and Universidad de Santiago has subscribed to it, so academics can log in through the university account.

He says that information at a scientific level is increasingly democratising. “Many things have changed in science, like open access articles (PDF) which publication costs are paid by the authors and networking sites, like ResearchGate, a sort of “Facebook” for scientists,” he adds.

Goals and expectations

Dr Azócar expects to continue both publishing and reviewing at an international level. “Being considered at a global level is very interesting. They should know that there are people in Chile with a voice to give opinions on specific issues,” he explains.

He says that the journal has helped him in his professional positioning and career. “All these references help scientists to be good professionals, to be formally recognized and valued by the university. Besides, this benefits my future research work, because it gives me more credibility in my field of work. In the scientific career, the scientist is constantly growing up in time,” he concludes.

Translated by Marcela Contreras