• Dr Paula Zapata, professor at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile, developed a fungicidal plastic film that degrades in a maximum of three years. This innovative product seeks to solve a common problem in food industry: the contamination by microorganisms produced between the production stage and the acquisition of the product by consumers.

   

  Dr Paula Zapata, professor at the Faculty of Chemistry and Biology of Universidad de Santiago developed a double function package that seeks to solve a common problem in food industry: the contamination by microorganisms produced between the production stage and the acquisition of the product consumers. The project has been funded by the Fundación para la Innovación Agraria (FIA) and the Metropolitan Regional Government.

  According to the project’s principal investigator, in comparison to other existing products, this new packaging is a contribution, “first, for its fungicidal properties, and second, as it is made up of an eco-friendly polymer, it is environmentally sustainable.” 

  To develop this film, the research team sought non-toxic natural agents and nanoparticles in order to keep food innocuousness and human safety.

  Transfer to the market

  Dr Zapata explains that this technological development can be used in different types of industry, then she thinks that the product’s transfer to the market is very achievable. For this reason, on December 06^th, they presented the results of their work before several companies like Soprole, Multi Sport and Agrosuper, among others.

  “I expect the technological transfer process to be successful. The transfer involves different difficult stages, but with work and a good communication with the companies, and learning what they want and what they need, we will be able to achieve it,” she says.

  According to Juan Pablo Castro, Corporate Manager of the Flexible Packaging Division of Bo Packing, this project means a great contribution to the market, as they have been looking for a solution to the problems mentioned above for years.

  “I think the relation between the university and the companies is of great importance. I am a chemical engineer, so I feel involved in this research projects. Our doors are open to innovation, as it is the only way in which a country can develop 

  During the meeting, Osvaldo Quiroz, who is responsible for Networks and Outreach and Engagement at the Department of Technology Transfer of the Vice Presidency of Research, Development and Innovation, offered the company representatives the possibility of working in partnership with Universidad de Santiago.

  Undergraduate and graduate students at the Department of Chemical Engineering and the Faculty of Chemistry and Biology participated in the project, which also had the collaboration of Dr Franco Rabagliati, professor at the Department of Environmental Sciences.

   

  Translated by Marcela Contreras

• Dr. Claudio Vasquez investigates the resistance of microorganisms in the Antarctic to tellurite, a derivative of metallic tellurium, which is very harmful and toxic to the environment.

Tellurium is a very scarce element in the earth's crust and its biological role is unknown to date. Although in its elemental state (Te ° metallic tellurium) it exhibits no toxicity, some of its derivatives, such as tellurite, are highly damaging to most bacteria.

In this context, Dr. Claudio Vasquez, professor at the Faculty of Chemistry and Biology at the U. of Santiago will be in charge of the Fondecyt project: "Antarctic tellurite-resistant bacteria: new mechanisms of resistance",  for three years.

The academic works with bacteria isolated in Antarctica, in order to analyze how the microorganisms react in a cold context in contact with the toxic. For the research, 800 toxic- resistant microorganisms, coming from 100 different Antarctic samples, were isolated. "Of all the samples, we chose four which showed greater resistance to unveil the defense mechanisms they use," the researcher says.

Dr. Vasquez adds that "over the years, we have identified proteins that help the cell to remove this toxic and, therefore, we think that these bacteria that have received more stress by being in extreme conditions at the Antarctic, could exhibit more sophisticated mechanisms. Our goal is to find new genes that encode novel proteins involved in the defense against these toxics.” the expert says.

As a projection of this study, the introduction of new genes into plants that grow in tellurium- contaminated environments, such as some mining areas, is expected. This would help the plants so that they can eliminate the polluting elements.

Pollution

The tellurite, produced as a result of industrial pollution, drains in groundwater by inhibiting or eliminating microorganisms that might be beneficial. It affects bacteria, fungi, plants and animals. For this reason, it is important to control the discharges which come from industrial exudates containing tellurium.

Tellurium is the molecular basis of solar cells that collect energy; therefore, any accident that might happen with these solar panels could release toxic elements.

• Researchers at the Food Science and Technology Research Center of Universidad de Santiago de Chile (CECTA- USACH, its acronym in Spanish) will participate in a Fondef project that seeks to improve enzymes’ ability to produce lactose-free milk in cold conditions, increasing the efficacy of the dairy products industry. In partnership with members of the Chilean Antarctic Institute (INACH, its acronym in Spanish), they will search for enzymes in different microorganisms from the Antarctica that would allow working at low temperatures. In Chile, 60% of the population suffers from lactose intolerance.

 

Lactose intolerance is a condition that affects millions of people all over the world. It is estimated that 30 to 50 million people in the United States suffer, to some degree, from this condition. An estimated 90% of the Asian population has the same problem, just like 60% of the Chilean population.

Lactose is a type of sugar found in milk and other dairy products. The body needs an enzyme called lactase to break down lactose. Lactose intolerance occurs when the small intestine cannot produce enough lactase. This is the reason why lactose content in milk has to be reduced, so that people suffering from this condition are able to drink it.

The project expects to detect an enzyme that allows breaking down lactose at low temperatures and at a better level of efficiency than the one of the enzyme currently used in the industry. Researchers will search for this enzyme in different microorganisms (fungi, yeasts and bacteria) that have been already isolated and brought from the Antarctic continent.

Once the efficacy at low temperatures of this “Antarctic enzyme” is described and tested, the project will be able to move forward to obtain the resources required for creating the conditions to transfer this biotechnological product to the industry.

In this way, finding enzymes which are highly effective in reducing the lactose content of milk at low temperatures will not only allow to optimize some of the current production processes, but it will also open new possibilities for the design of lactose-content reducing processes in cold conditions and for the production of lactose-free foods.

The project called “Antarctic enzyme with highly effective β-galactosidase activity to reduce lactose content of milk at low temperatures” (ID14I10098) will last for two years and will be funded by Fondef and Universidad de Santiago. It will be led by Dr Renato Chávez Rosales (Director), professor at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile, and Dr José Luis Palacios Pino (Alternate Director), researcher at Cecta-Usach.

The experts will work in partnership with members of the Chilean Antarctic Institute in the search for the enzyme in different microorganisms brought from the Antarctica.

Translated by Marcela Contreras

• “Universidad de Santiago has all the potential to be number one in most areas (of research in the country),” Dr Pablo Zamora, Scientific Director of University of California Davis in Chile, says. The institution opened its centre in Santiago last April, thanks to the CORFO’s Program Attraction of International Centres of Excellence. He adds that his institution is interested in the possibilities of research and development in biology, chemistry and agricultural management, among others.

Dr Pablo Zamora, graduate of the Faculty of Chemistry and Biology of Universidad de Santiago and current Scientific Director of University of California Davis in Chile, proposes a research model based on demand. Last April, this institution established a research centre in Chile thanks to the CORFO’s Program Attraction of International Centres of Excellence.

On April 21^st, President Michelle Bachelet opened the UC Davis-Chile Life Sciences Innovation Centre in Santiago, Chile, a worldwide example in the development of research and solutions in agriculture, forestry and life sciences.

The founding academic partners are Universidad de Tarapacá, Universidad de Talca and Universidad Andrés Bello, while the corporate partners are Viña Concha y Toro and Viña San Pedro-Tarapacá. Currently, Universidad de Santiago de Chile is in the process of ratifying its incorporation to UC Davis Chile.

Dr Pablo Zamora, graduate of the Faculty of Chemistry and Biology of Universidad de Santiago and PhD in Biotechnology, leads the scientific area of this initiative and is in charge of facing this new challenge of doing science form a perspective that strengthens the links between the corporate and the academic worlds.

Interest

“We are interested in Universidad de Santiago for its research and development capabilities in biology, chemistry, agriculture and agriculture management in the Technological Faculty. Another big advantage is the capability that the University has in engineering issues,” Dr Zamora says.

Universidad de Santiago will be represented by Dr Alejandra Moenne, professor at the Department of Biology of the Faculty. She will be the technical counterpart in the Scientific Board of US Davis Chile. She will be in charge of leading research proposals and representing the University in the projects managed in partnership by both institutions.

“We see Universidad de Santiago in different roles. For example, in the area of applied research, with its laboratories and also in development issues,” he says.

“The UC Davis Chile research model is different, but not original. It is based on the demand. In Chile, this has not been well developed because companies have little capacity to generate research. There is also a sort of dissociation between the companies’ challenges and the research conducted by universities,” he explains.

UC Davis Chile focuses its work on four large areas: wine making, post harvest and climate change technologies and genetic improvement.

“In order to make sure that research projects will really have an impact on industry, we will meet with companies, learn about their problems and analyze the knowledge and services offered by UC Davis and its national academic partners to formulate projects to solve those problems. This seems quite obvious, but it usually does not occur,” he says, regarding the way in which UC Davis Chile works.

“Not all companies consider scientific research as a tool that can make them more productive. UC Davis has a large experience in collaborating and generating solutions for the production problems that companies have. This allows them to start seeing research as a means to enable increased competitiveness,” he adds.

Back in Chile and at the University

For this graduate of the Faculty of Chemistry and Biology and current member of the staff of the doctoral program in biotechnology, collaborating with the University is not only a matter of being fond of the University; he thinks that Universidad de Santiago “has all the potential to be number one in most areas (of research) in Chile.”

“Being back at the Faculty is very gratifying. Its progress is evident and, for this reason, I have full confidence that Universidad de Santiago can be number one at a national level,” he says.

Ministry of Science

With regards to President’s Bachelet announcement of the creation of a Ministry of Science, Dr Zamora says: “It is valuable, because, in some way, it makes science visible, but it does not guarantee the development of better science in Chile. As a scientist, I think it is valuable, but I believe that there should be a focal point and clear guidelines, and because we are a country with little resources, some strategic areas should be clustered together and strengthened,” he says.

“I think that the State should make an effort in involving and building links with the productive sector. In turn, the private sector should commit itself to allocate more resources for research and development. UC Davis in Chile will contribute to strengthen the relation science-industry, together with other institutions. Is this happening? Yes, it is. Are we on the right track? I believe we are. Is all this happening at the speed the country requires? I think it is not, but things don’t happen from one day to the next,” he concludes.

Translated by Marcela Contreras

•  Dr Claudio Laurido, professor at the Faculty of Chemistry and Biology of Universidad de Santiago, is studying the reduction of chronic arthritis pain by using drugs administrated via extended-release nanoparticles. “Currently, very strong injectable drugs are required, like morphine, with several undesirable side effects. The purpose of using these nanoparticles is to administrate lower doses of drugs, hopefully, with less side effects,” the researcher said.

According to the Chilean Ministry of Health, 1% of the population suffers from rheumatoid arthritis, mostly women between 45 and 75 years old.

Dr Claudio Laurido, professor at the Department of Biology of Universidad de Santiago, seeks to use drug-loaded extended-release nanoparticles to inhibit arthritis pain, by injecting them into the lumbar cerebrospinal fluid. 

“Currently, very strong injectable drugs are required, like morphine, with several undesirable side effects. The purpose of using these nanoparticles is to administrate lower doses of drugs, hopefully, with less side effects for patients,” the researcher says.

The study "Manufactura de nanopartículas de liberación prolongada de fármacos, caracterización y ensayo en ratas monoartríticas" (Development of drug extended-release nanoparticles. Characterization and testing in monoarthritic rats), will last for three years and is funded by the Scientific and Technological Research Department (Dicyt, in Spanish) of Universidad de Santiago.

The researcher says that there is evidence that chronic pain can kill a person. If pain is not controlled, it can affect the immune function, stimulate tumor growth, and cause depression, increasing the risk of suicide in patients.

“Common drugs are not the solution, as they relieve acute pain, which may be strong, but then it is reduced until disappearing. Chronic pain persists in time,” he adds.

For this reason, this study is focused on analyzing the neurobiological bases of chronic pain and identifying the cells involved in the processes that start, develop and maintain chronic arthritis pain.

Contributing to neurobiology

Dr Alejandro Hernández, co-investigator in this study, suggests the possibility of modulating spinal pain mechanisms by suppressing the communication between the glial system and neurons with drugs. For this purpose, the study will develop nanoparticles loaded with drugs that improve the cerebral blood flow.  

In this study, nanoparticles will be made of biocompatible and biodegradable materials, like lipids and other products used in the food and cosmetics industry.

“These nanoparticles are used for their ability to encapsulate and release drugs over time. A common pill does not have this ability and lasts for a maximum of 4-6 hours. In this case, only one dose is totally effective,” Dr Laurido explains.

With this study, the researcher expects to contribute to the field of neurobiology. Extended-release nanoparticles allow to place drugs close to the area where the pain is generated (spinal cord), using much lower doses, reducing the administration frequency, reducing or eliminating undesirable side effects and increasing drug effectiveness. It will be a great contribution to the study of pain.

Translated by Marcela Contreras

• The work of the CESS Oxford-U de Santiago was evaluated by the Newton-Picarte Fund as one of the best projects.

The funding allocated by this program of the British Government will allow the Center to continue its path to become a hub of experimental research in Social Sciences in Latin America. It will allow promoting the training of PhD students and professors in experimental research, particularly in experimental methods for the analysis of public policies.

The Newton-Picarte Fund program is a partnership between the Chilean’s National Commission for Scientific and Technological Research (Conicyt, in Spanish) and the British Government to support scientific research in Chile, particularly in joint research projects involving Chilean and British scientists, technology transfer and innovation, advanced human capital development for research and innovation, and the generation of  challenges that provide innovative solutions for the development of our country. 

Funding allocation

Raymond Duch, Director of the Center for Experimental Social Sciences Oxford-Universidad de Santiago, explains that the most important contribution of this fund is that it will allow providing training to policy makers in Chile.

“This training will help them to apply experimental methods to design more effective and efficient policies in different areas. First, we will focus on Education, but in the long term, we will include other important areas of Chilean politics,” he emphasizes. Besides, the fund awarded will finance a workshop with renowned social scientists worldwide.

“It will be a unique opportunity for students in Chile to meet with policy makers and analysts and discuss the current policies faced by the Chilean Government and also give ideas on how to make policies that meet their goals. For example, a way of improving job opportunities for Chilean youngsters who have problems to enter the labor market,” he says.

The Newton-Picarte Fund will allow the Center to offer its training programs, research and educational possibilities to a wide variety of Chilean academics, the Government and the private sector.

“The training courses that we have developed for our partners in the Chilean Government will be available for ministries, students and teachers as well as decision-makers in the private sector,” Director Duch concludes.

The funds were awarded after a highly competitive process in which the CESS Oxford-U de Santiago was among the best evaluated projects.

Translated by Marcela Contreras

• The implementation of this new research instance was announced by the University’s President, Juan Manuel Zolezzi, on December 3rd, during the launching of a Program for Institutional Improvement (PMI, in Spanish), funded by the Ministry of Education. The purpose of this new Information Technology Innovation Center for Social Applications (Citiaps, in Spanish) is to be an intermediary between research and its viability as software products that could be commercially developed, based on the premise of integrating innovation and science.

The PMI was created by this Corporation as a strategy to achieve world-class excellence in an innovative way, integrating three research areas to develop science- based innovation: Information technology, psychology and neuroscience. The University was awarded a grant from the Ministry of Education’s contestable fund to finance the program through a performance agreement.

“With this project we intend to improve our international competitiveness, increase the University’s scientific productivity in a significant way, and reach higher levels of teaching and scientific discoveries. All this will be done through the highly specialized and interdisciplinary research centers that we already have and through others that we are committed to create,” said President Zolezzi.

In the program’s launching ceremony, held on December 3rd in the University’s Salón de Honor, the University’s President said that the PMI will outline the future of applied research and that a significant share of this goal will lie on this new Information Technology Innovation Center for Social Applications.

Applied innovation for society

“The Citiaps will integrate the work done until now and it also considers the technological origins of this University and the great development of social sciences during the last years,” President Zolezzi said, emphasizing at the same time the center’s efforts to develop strategic partnerships among researchers, entrepreneurs and companies, doing a state-of-the-art interdisciplinary work.

“The PMI will strengthen the Vice Presidency of Investigation, Development and Innovation (Vridei, in Spanish) and to consolidate a technology transfer platform to do research in association with companies and to transfer and commercialize the R+D results,” the President added.

Oscar Bustos, Vice President of Investigation, Development and Innovation said that, although the Citiaps will be focused on three main areas (Information technology, psychology and neuroscience), its goal will be to cover all disciplines. “We want our students- who are very creative- to channel their ideas through the center, so that researchers develop these ideas and create products which are useful to society.”

“The idea is to generate innovation based on high-impact science. We have set ambitious but real goals,” the Vice President said.

Contributing to the country

Alberto Vásquez, Head of the Ministry of Education’s Higher Education Division, referred to the excellent assessment that the PMI had during the contest, which meant being granted the funds, and to the significance of contributing with new knowledge for Chile. “We would like to congratulate and support this initiative and say that for our country is good, important and relevant to award this performance agreement to Universidad de Santiago.”

John Fraser, American expert and professor at the Florida State University, who was a special guest at the ceremony, valued this interdisciplinary initiative from an international point of view saying that this was the best moment to invest in knowledge and to promote creativity, considering the economic success of the country.

Finally, Luis Magne, Head of the Vridei’s Technological Management Department awarded the winners of the First Patent Contest for Students: Roberto Santiago, from the Department of Chemical Engineering; Jaime Lagos and Álvaro Espejo, from the Department of Physics; Camila Manfredi, from the School of Architecture, and Loreto Acevedo, from the Department of Food Science and Technology.

Fernando Vial, Head of the Ministry of Education’s Institutional Financing Department; Mauricio Marín, PMI and Citiaps’ Scientific Director; Pablo Vera, Citiaps’ Deputy Scientific Director; Ramón Blasco, Dean of the Faculty of Engineering; Rafael Labarca, Dean of the Faculty of Science, Augusto Samaniego, Dean of the Faculty of Humanities, and other authorities, also attended the ceremony.

Translated by Marcela Contreras

• The projects supported by the Department of Agrarian Management of the Technological Faculty and the Food Science and Technology Research Center of Universidad de Santiago show important results, like a bio-pesticide based on residual quinoa grains or the potential edible use of this pseudo-cereal leaves.

The projects supported by the Department of Agrarian Management of the Technological Faculty and the Food Science and Technology Research Center of Universidad de Santiago (Cecta, in Spanish), show important progress in their goal of feeding the population in a healthy and equitable way.

The first project, “Biopesticidas en base a saponinas de quínoa” (Bio-pesticides based on quinoa saponins) (FIC 30343624-0) lasts three years and it is being developed in the O’Higgins Region, in Central Chile. It has the purpose of using the residual quinoa grains to generate a natural pesticide for grapevines.

The second project, “Valorización agroindustrial de subproductos de la quínoa” (Agro-industrial valuation of quinoa byproducts) (FIC 30429825-0), lasts three years and it is also being developed in the O’Higgins Region. The goal of this project is to promote the cultivation of quinoa, with new applications. Besides using the grains, they expect to promote the use of the leaves in salads.

The third project, “Habilitación de productores hortícolas de la región Metropolitana para la elaboración de productos IV gama” (Training vegetable producers of the Metropolitan Region in the elaboration of IV range products) (GORE BIP 30442786-0), lasts 18 months and it is the continuation of a project developed by the Cecta researchers in 2011 that tested different protocols to reduce the microbial load in vegetables like lettuces, cabbages and carrots.

Carlos Díaz Ramírez, Professor at the Department of Agrarian Management and Innovation Manager of the projects, explains that the purpose of this project is to train small farmers in the care and safety of all the production and supply chain of vegetables, until the products reach the consumer.

Some of the Cecta scientists involved in the projects are Professor Lina Yáñez Catalán, Dr Claudio Martínez and Dr José Luis Palacios Pino.

• The project, funded by CORFO, is led by Dr. Claudia Ortiz, researcher at the Faculty of Chemistry and Biology, and it focuses on developing a biological filter using brown algae, enhancing copper and arsenic recovery from the water used in the mining process. The filters can also be used as desalination agents. This involves the real possibility of using seawater as an alternative to mining production processes.

Water consumption in Chile’s mining industry is now a multi-faceted problem. Water shortage in large deposits of minerals located in the center and northern part of the country, the disadvantages of the systems available for water treatment, and the figures, show that 95 percent of the recourse that enters the plants ends up as waste.

Given this reality, the project led by Dr. Claudia Ortiz, researcher at the Faculty of Chemistry and Biology, aims to obtain a biofilter prototype (biological filters) based on Chilean brown algae, which are chemically modified for the absorption of large concentrations of elements such as copper and arsenic.

In words of the researcher, "the direct recovery of copper, by using biofilters, will cause productive benefit and also an increase in the life cycle of the water process, resulting in more efficient resource usage. Also, the content of elements, such as arsenic and copper, will decrease. Their presence in the environment is a global problem because of the persistence, bioaccumulation and toxicity to living organisms. "

This project corresponds to one of the six initiatives of the Applied R & D project funded by CORFO, which the University will run.

Because of its high efficiency at low concentrations of heavy metals and its low cost, the filters may also be used as desalination agents and this means the real possibility of using seawater, as an alternative to mining production processes.

"The project involves a comprehensive solution, which is efficient and cheap to industry. Currently, this field faces three problems: access to water resources, optimization of copper production, by recovering this metal from the waste, and the use of sea water in the process," Dr. Ortiz says. She adds that in a first phase, the project includes the development of laboratory-scale biofilter prototype and then the project scaling to industrial level.

The project is conducted by: the Department of Biology of the Faculty of Chemistry and Biology; the Department of Geographic Engineering of the Faculty of Engineering, and the Department of Mechanical Engineering, as hydro-specialized support, as well as Good Harbour Technologies a Canadian company specialized in process scaling, and División Codelco Chuquicamata, as associated with the project.

• A plastic bag takes 1,000 years to break down. In light of this situation, biodegradable materials have become a good option. This is the context in which the study led by Dr Ana Carolina López Dicastillo, a member of the Center for the Development of Nanoscience and Nanotechnology of Universidad de Santiago, is being conducted. Thanks to the electrospinning technique, her research team will produce nanoparticles able to enhance the properties of biodegradable materials in order to obtain, in the long term, more eco-friendly packaging.

It is widely known that a plastic bag takes 1,000 years to break down, causing harm to the environment. Biodegradable materials are an alternative to solve this problem, because they are highly beneficial to the environment when they are adequately discarded. However, these materials do not have the same barrier and mechanical properties that petroleum-based products do, so they become fragile and highly permeable.

Thanks to the electrospinning technique, the research team will produce nanoparticles able to enhance the properties of biodegradable materials in order to obtain, in the long term, more eco-friendly packaging. The study is led by Dr Ana Carolina López Dicastillo, a member of the Center for the Development of Nanoscience and Nanotechnology of Universidad de Santiago, (Cedenna, in Spanish).

This Regular Fondecyt project, which is in its second year, seeks to improve the properties of a biodegradable material by incorporating nanoparticles produced by electrospinning to eventually use this material for food packaging. The electrospinning technique has not been frequently used in our country.

The electrospinning process allows obtaining fiber by means of the coaxial stretching of a viscoelastic solution. The diameter of the electrospun fibers ranges from microns no nanometers and they may have unique features.

Due to its interesting properties, this technique has been widely studied in the past few years for a wide variety of applications, like tissue engineering, the creation of special membranes and medical applications like dental implants and bone replacement. In this case, the project is oriented to enhance the properties of biodegradable materials for food industry applications. “Besides developing and working with nanoparticles and nanofibers, this technique allows encapsulating active compounds for their further release, what is also important in the food industry,” Dr López said.

The study seeks to enhance the essential properties of a biodegradable polymer and to create a biodegradable packaging with antioxidant and antimicrobial properties to protect food and to extend its shelf life.

Dr. López Dicastillo, who is responsible for the study, explains that “one of the expectations that we have with this work is trying to implement the concept of reducing plastic products in daily life, replacing traditional materials with biodegradable ones and the awareness of recycling and sustainability.”

She has the goal of making people aware of the problem posed by the plastic waste buildup and the need for replacing petroleum-based products with biodegradable materials, as petroleum is not a renewable resource.

“However, these (biodegradable) materials do not have the properties that the market demands yet. This is why we propose to enhance them and one of the solutions to this problem is nanotechnology. In our project, we are developing a type of nanoparticle that can make biodegradable materials properties to be similar to the ones of traditional plastic products in the market,” she said.

“We also intend to disseminate this study at different levels: from teaching children the importance of these existing biodegradable materials, emphasizing the need for recycling, to scientific conferences and presentations,” the researcher concluded.

Translated by Marcela Contreras