• In large cities like Santiago, the quality of life is strongly related to the quality of the environment of the urban settings we live in. This is the core idea of the study “Socio-ecological quality in urban settings: improvements for a human-scale sustainable environment. Municipality of Quinta Normal,” a Dicyt project developed by Dr Alexandre Carbonnel and Rodrigo Martin, both professors at the School of Architecture of Universidad de Santiago. The study seeks to provide a tool for assessing the quality of urban life, considering environmental conditions (thermal, acoustic, and atmospheric ones) at urban settings.

   

  “Socio-ecological quality in urban settings: improvements for a human-scale sustainable environment. Municipality of Quinta Normal,” is the name of the study conducted by Dr Alexandre Carbonnel and Rodrigo Martin, both professors at the School of Architecture of Universidad de Santiago. The project has been funded by the university’s Scientific and Technological Research Department (Dicyt, in Spanish) and it has the purpose of providing a tool for measuring the quality of urban life, considering environmental conditions (thermal, acoustic, and atmospheric ones) at urban settings.

  The first measurements will be done at the municipality of Quinta Normal, an area of the capital of 12.4 square kilometers wide, with a population of 105 thousand people, according to the national census of 2002.

  This municipality is significant for the study, as it displays several special characteristics: In spite of being close to Santiago Centro, it has several industries; it adjoins Quinta Normal Park, one of the largest green areas of the capital managed by the Municipality of Santiago; and it is traversed by some of the busiest streets of the city, like Matucana, Costanera Norte Highway, Avenida San Pablo, and Central Highway (General Velásquez).

  The first hurdle to be cleared was to define the study areas. For this purpose, the research team developed “a methodology to identify the use of the urban setting as of the use of transportation and schools, what will allow pinpointing the nodes of very intense use and measure their environmental quality,” Carbonnel said.

  In order to relate the urban environmental quality to the use of urban infrastructure and services, variables and indicators related to transportation, health care and education coverage, cultural and commercial spots, green areas, and others, will be analyzed. The researchers will use some software programs (QGis and Grasshopper3d) to cross-check the information and identify the places with higher people density and more use of space.

  Once they know the places with higher density and more use, they will measure the urban environmental quality. This process will be based on thermal, acoustic and atmospheric variables, providing a true and varied environmental record of the places to be studied 

  Study impact

  According to Dr Carbonnel, the study impact is aimed at “providing municipalities, regional governments and the community with an important information tool that includes environmental indicators to orient them at managing and making local public policies and to contribute to a better use of the funds invested in infrastructure.”

  Dr Carbonnel also said that this methodology will open doors to the creation of a new line of products. “These innovations should aim to democratizing environmental information, in agreement with the vision of the Smart City Lab research center of our university.” Both researcher work at this center, together with other professionals of the School of Psychology and the Departments of Industrial Engineering, Geographic Engineering, Electric Engineering and Computer Engineering.

  Translated by Marcela Contreras

• With a space of 2,755 m², the five-floored building will be home to the Center for the Development of Nanoscience and Nanotechnology, the Aquaculture Biotechnology Center and the Soft Matter Center. The cost of the building construction amounted to about CLP 5,000 million.

In a context in which Chile only invests 0.39 of its GDP in research, the President of Universidad de Santiago de Chile, Dr Juan Manuel Zolezzi, highlighted the importance of this new space that will contribute to research and development in the country.

“This is one of the state-of-the arts buildings in Chile with regard to university research and it is an incentive for new researchers to continue innovating in key areas for the development of Chile,” he said. He added that Universidad de Santiago de Chile is a leader in technology transfer.

Senator Guido Girardi, who heads the Challenges for the Future. Science, Technology and Innovation Commission of the Upper House, valued the work done by public universities.

“These universities take charge of basic sciences on their own. Particularly, Universidad de Santiago has had the wisdom to connect basic sciences to the problems of the country and to generate innovation to solve these problems,” he said.

A few months ago, Dr Girardi visited the Center for the Development of Nanoscience and Nanotechnology (Cedenna, in Spanish) where he met with professionals in this significant research field. After the opening ceremony he congratulated the university on the new facilities.

The centers

Representatives of the centers that will occupy the new facilities expressed their satisfaction with the architectural configuration of the building that facilitates research development.

Dr Francisco Melo, Head of the Soft Matter Center that gathers together scientists in the fields of Physics, Chemistry, Biology and Engineering, said that the new space will offer endless opportunities for a better science development and for positioning the university at an international level.

For her part, Dr Dora Altbir, Head of the Cedenna, said that the possibility of bringing together scientists from different fields will allow a more active collaboration than the one that the university has now.

Eugenio Spencer Ossa, Head of the Aquaculture Biotechnology Center (CBA, in Spanish) said that the new building will allow to further scientific research and contribute to improve domestic industrial production, like salmon farming.

Architecture

The Rector Eduardo Morales Santos Research Building, with a total surface of 2,755.15 m², is located in the central campus of the university. Its design is a geometric reinterpretation of the heritage buildings of the institution designed by the architects Héctor Valdés, Fernando Castillo Velasco, Carlos García Huidobro and Carlos Bresciani and built between 1957 and 1967. The building’s name is a tribute to the first democratically-elected university president after the dictatorship.

Translated by Marcela Contreras

• After the success of Nutrisato- an innovative natural fertilizer that increases by 50% the size of fruits, vegetables and plants- in the international market, its creators opened an agricultural additives company.

In his search for environmentally friendly biotechnological solutions, Alejandro Muñoz, biochemist and student at the Biotechnology doctoral program of the Faculty of Chemistry and Biology of Universidad de Santiago, developed an interesting plant biostimulant based on organic molecules which is able to increase fruits, vegetables and flowers twice their size in the same period of time.

Later, Carla Céspedes, an agronomist from Universidad de Chile, and Rodrigo Ferreira, student at the Commercial Engineering program of the Faculty of Administration and Economics of Universidad de Santiago de Chile, joined the project team and took the responsibility of placing the product in the agricultural market.

After the positive outcomes of testing Nutrisato in peppers and tomatoes, the students participated in the Brain Chile program contest and won the first place. They used the funds that they were awarded to continue developing the product to a level that they never expected: today, they have their own company called Ingeniería y Biotecnología Limitada, Atama Biotech Ltda.

Nutrisato in the market

After the Brain Chile Contest, they continued testing Nutrisato. They found that it was harmless to people and the environment and it also “doubled the size of the products, increased the production of fruits by 50% and the production of biomass in vegetables by 30%,” Alejandro Muñoz explained.

Carla Céspedes, who is responsible for the agronomic development of Nutrisato, explained: “The first products in which we tested the biostimulant were harvested in April, but after the contest, they were left abandoned in an area with Andean climate. In that context, we realized that the fertilizer reduced the cold stress in plants and enhanced their hygroscopic properties.”

Supported by recent tests, the researchers confirmed that the fertilizer worked in every product in which they used it, like spinach, celery, parsley, coriander, tomatoes, peppers, onions, cherry tomatoes and ornamental plants like tulips, roses and daisies.

Now they are testing the product in hydroponic lettuces and tomatoes, and in berries and citrus fruits, in Valdivia.

With regard to the marketing of the product, Rodrigo Ferreira, who is in charge of the company’s management and sales, says that they created Nutrisato Hogar, a product which is targeted at people who grow their own vegetables in home gardens. The product will be in the market soon.

The researchers say that they have enjoyed their work with Nustrisato, because they are doing what they like to do. For this reason, they have continued developing innovative products, like Raizato. “Raizato is a super soil enhancer that adds organic matter to the soil and enhances the growth of roots and leaves,” Alejandro Muñoz said.

Translated by Marcela Contreras

• Universidad de Santiago’s Innovo Center was awarded these funds to run the Flexible Allocation Seed Grant Fund for four years in order to accelerate the development of innovative scientific and technological business ventures of international impact.
• “This grant is in recognition for the work done by the Center’s Business Incubator, which has dedicated itself to promote the innovation and entrepreneurship culture and has helped to create new technology-based companies,” Innovo’s Director said.

In order to strengthen scientific and technological business ventures, the Chilean Economic Development Agency (CORFO, in Spanish) awarded Universidad de Santiago’s Innovo Center 2,600 million pesos to run the Flexible Allocation Seed Grant Fund (SSAF, in Spanish) for four years. These funds will be earmarked for supporting innovative, high-impact start-up companies.

“The objective is to accelerate the development of local scientific and technological business ventures at an early commercial stage which are based on technologies in their last mile of development and have a potential international impact. We have 500 million pesos available for the first year and then, 700 million pesos every year,” Luis Lino, Innovo’s Director, explained.

These resources will be given to scientific and technological entrepreneurs through contestable funding. Those who are interested and meet the requirements will have to apply for it. For the business ventures that are granted SSAF funds, Innovo Center considers a first stage of international commercial validation. For this purpose, Innovo has 10 million pesos available, and for the second stage of commercialization support, it has 50 million pesos. Both stages require co-funding, as entrepreneurs will have to provide 25% of the total cost of the project.

“The contestable funding call will include entrepreneurs with technological projects, as well as other Chilean academic or research centers. The first call is scheduled between August and October this year and the projects will be evaluated according to their innovation degree, teamwork, technology development and their impact on the country,” Lino explained.

In Director Lino’s opinion, this grant is in recognition for the work done by the Center’s Business Incubator, which has dedicated itself to promote the innovation and entrepreneurship culture and has helped to create new technology-based companies.

Today, 33 companies are being incubated in fields like engineering, life science, biomedicine, and information technology with impact on industry. Some business ventures that are worth to mention are the development of a tidal power harvesting equipment, a biotechnological treatment for mining industry liquid wastes, the first electric car developed in Chile and a new energy dissipation system for buildings, among others.


Translated by Marcela Contreras

• In order to develop more tolerable therapies, a research team at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile studies the use of biodegradable nanoparticles to increase the Adenosine Triphosphate (ATP) circulation time in the body to combat cancer.

In order to develop more tolerable therapies, a research team at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile studies the use of biodegradable nanoparticles to increase the Adenosine Triphosphate (ATP) circulation time in the body to combat cancer.

The study is led by Dr Patricia Díaz, professor at the Faculty of Chemistry and Biology and is being developed in the context of the 2016 Fondecyt Post Doc Project (3160837) "Uso de nanopartículas con circulación prolongada para la administración de ATP en tratamientos anticancerígenos." Dr Díaz and her team will test new nanotechnology-based applications to deliver cancer-fighting drugs into the body.

She explains that any drug delivered in the body for therapeutic purposes requires a circulation time to play its therapeutic role.

Some molecules, like ATP, are quickly degraded, so high constant drug doses are required to be therapeutically effective and this is not beneficial for patients.

“As drugs are encapsulated in nanoparticles, the enzymes that metabolize them cannot bind to them. This is why they are protected against degradation. Consequently, drugs’ half-life is increased, prolonging its therapeutic efficacy,” she explains. 

Improved treatments

The advantage of using ATP as a cancer-fighting drug is that it has minor side effects if compared to other drugs. But ATP degrades very quickly when it is recognized by the enzymes in the body. Therefore, different drug administration methods are required, like the use of nanoparticles with biodegradable and biocompatible properties.

“For this reason, we want to encapsulate ATP into biocompatible nanoparticles to increase its half-life. We will also use other strategies to make them invisible to the immune system, so that they can circulate longer. The idea is to prevent them from binding to the cell and to avoid extracellular release of ATP. In this way, we expect to have a higher amount of drug available in the body for a prolonged anti-cancer effect,” she explains.

According to Dr Díaz, the main objective of the study is to test the effectiveness of ATP-carrying nanoparticles in cancer treatment. “I expect to demonstrate that nanoparticle-encapsulated drugs increase their bioavailability when compared with conventional administration methods. Besides, we also expect to analyze the potential synergistic effect of administrating ATP in combination with other drugs frequently used in cancer treatment.”

“This synergistic effect could destroy a higher number of cancer cells, benefiting patients with advanced cancer,” she adds.

Another advantage of this type of treatment is that, as it allows a sustained release of drugs in time, patients could receive the treatment once a week or every two or more weeks, depending on the drug encapsulation capacity and its circulation time,” she concludes. 

Dr Juan Pablo García-Huidobro, researcher at the Faculty of Chemistry and Biology, is also participating in the study, which is being conducted at the Pharmacology Laboratory.

Translated by Marcela Contreras

• With a space of 2,755 m², the five-floored building will be home to the Center for the Development of Nanoscience and Nanotechnology, the Aquaculture Biotechnology Center and the Soft Matter Center. The cost of the building construction amounted to about CLP 5,000 million.

In a context in which Chile only invests 0.39 of its GDP in research, the President of Universidad de Santiago de Chile, Dr Juan Manuel Zolezzi, highlighted the importance of this new space that will contribute to research and development in the country.

“This is one of the state-of-the arts buildings in Chile with regard to university research and it is an incentive for new researchers to continue innovating in key areas for the development of Chile,” he said. He added that Universidad de Santiago de Chile is a leader in technology transfer.

Senator Guido Girardi, who heads the Challenges for the Future. Science, Technology and Innovation Commission of the Upper House, valued the work done by public universities.

“These universities take charge of basic sciences on their own. Particularly, Universidad de Santiago has had the wisdom to connect basic sciences to the problems of the country and to generate innovation to solve these problems,” he said.

A few months ago, Dr Girardi visited the Center for the Development of Nanoscience and Nanotechnology (Cedenna, in Spanish) where he met with professionals in this significant research field. After the opening ceremony he congratulated the university on the new facilities.

The centers

Representatives of the centers that will occupy the new facilities expressed their satisfaction with the architectural configuration of the building that facilitates research development.

Dr Francisco Melo, Head of the Soft Matter Center that gathers together scientists in the fields of Physics, Chemistry, Biology and Engineering, said that the new space will offer endless opportunities for a better science development and for positioning the university at an international level.

For her part, Dr Dora Altbir, Head of the Cedenna, said that the possibility of bringing together scientists from different fields will allow a more active collaboration than the one that the university has now.

Eugenio Spencer Ossa, Head of the Aquaculture Biotechnology Center (CBA, in Spanish) said that the new building will allow to further scientific research and contribute to improve domestic industrial production, like salmon farming.

Architecture

The Rector Eduardo Morales Santos Research Building, with a total surface of 2,755.15 m², is located in the central campus of the university. Its design is a geometric reinterpretation of the heritage buildings of the institution designed by the architects Héctor Valdés, Fernando Castillo Velasco, Carlos García Huidobro and Carlos Bresciani and built between 1957 and 1967. The building’s name is a tribute to the first democratically-elected university president after the dictatorship.

Translated by Marcela Contreras

• The project led by Dr Silvia Matiacevich, professor at the Department of Food Science and Technology of the Technological Faculty, seeks to renew food industry by developing a compound with antimicrobial and antioxidant properties to prolong shelf life of dairy products. The project is funded through a Fondecyt Regular project 2016.

Nowadays, fresh, healthy and natural food consumption has increased, particularly, the intake of dairy products. According to the Chilean Bureau for Agricultural Studies and Policies (ODEPA; in Spanish), in 2013 the intake per capita was 146.5 liter, a national record in the country. 

However, these products require additives for their preservation that are not always natural and that do not allow a balanced and healthy diet.

In this context, Dr Silvia Matiacevich, professor at the Department of Food Science and Technology of the Technological Faculty; Dr Rubén Bustos, professor at the Department of Chemical Engineering of the Faculty of Engineering, and students at both units formed an interdisciplinary research team that will work on the study “Prolonged release of natural active compounds for improving shelf life of a dairy food matrix: Effect of structure obtained by different encapsulation process”. The project is funded by a Fondecyt Regular project (1160463) and it seeks to find a new active compound to preserve dairy products by means of nanotechnology. 

“We want to develop a new active ingredient with antimicrobial and antioxidant properties for dairy foods, in such a way that the compound has a prolonged release during storage, extending the product’s shelf life,” Dr Matiacevich says.

With this in mind, the researchers intend to study how the structure generated in this active ingredient- a powder developed through two different techniques- modifies its prolonged release in time in a real matrix,” she adds.

Food innovation and collaborative work

The objective of the study is to evaluate the effect of the structure obtained through “different encapsulation processes in prolonged release during storage of an encapsulated active agent,” in order to prolong the shelf life of a milk-based food matrix.

“By using encapsulation processes it is possible to obtain nanometric-sized particles, so the principles of nanotechnology are involved in this development,” favoring the compound prolonged release,” Dr Rubén Bustos, co-researcher of this study, says.

Food innovation research has increased worldwide. In Latin America, there are several research groups. For example, there are centers in Argentina, Colombia and Brazil, which professionals will collaborate in this project.

According to Dr Matiacevich, the main contribution of this study lies in that they will work directly with foods, so the study will not only provide basic knowledge but it will be applied to a real matrix.

For his part, Dr Bustos stresses the importance of their work with nanotechnology by saying: “At some point, microencapsulated ingredients were the greatest breakthrough, but now we will work with nanoencapsulated compounds, with much smaller and innovative structures.”

For the research team, the most important fact in relation to this project is that it involves the collaborative work of two departments of two different faculties of Universidad de Santiago de Chile. They also value the support of the Vice Presidency of Research, Development and Innovation, and the collaborative work with national and foreign universities. 

Translated by Marcela Contreras

• Dr Daniel Serafini and Dr Álvaro San Martín, both professors at the Department of Physics, have developed an innovative solution that allows to store energy as hydrogen. One of the advantages of this technology is that it is not intermittent as current non-conventional energy sources (NCES), like solar and wind energy. This project is a contribution of Universidad de Santiago de Chile to the energy industry.

An innovative technology to store energy as hydrogen is being developed by Dr Daniel Serafini and Dr Álvaro San Martín, both professors at the Department of Physics of Universidad de Santiago de Chile.

According to Dr Serafini, one of the advantages of this technology is that it is not intermittent as current non-conventional energy sources (NCES), like solar and wind energy.

Hydrogen is generated during off-peak periods via water electrolysis. Then, depending on the needs, electric power is generated using the hydrogen stored in an electrochemical device called fuel cell. This system is very efficient and is environmentally friendly, because hydrogen combustion only generates water vapour, free of greenhouse gases and particulate matter.

Storing energy as hydrogen is a better solution in comparison to lithium batteries. “We compete with lithium batteries and they are much more expensive and heavier and they have technological problems regarding their size, i.e., at equal size, they have a more reduced capacity,” Dr Serafini says.

According to the expert, with current battery technology, lithium reserves in the world “are enough to cover only 40% of the cars in the Unites States.”

It is also worth to mention that this solution is particularly attractive to settlements in remote areas that do not receive power supply from the interconnected grid system.

The researchers implemented a demonstration module at the Minera San Pedro mining camp, in Til Til (at the north of the Metropolitan Region), where the pilot project has been working since mid-2015.

The CLP150 million project has been funded by the Innova Chile program of the Chilean Economic Development Agency (CLP132 million) and Minera San Pedro.

Greater involvement of the private sector

For his part, Dr San Martín stresses that the project has been well received by the Government and that now, a greater involvement of the private sector is required. “In developed countries, different public and private programs to develop hydrogen technologies have been funded with millions of dollars for a long time,” he says.

State-run bodies in Chile have already recognized the importance of hydrogen in the future for a clean non-polluting public transport. Both researchers agree that this is an essential starting point. 

Target market

One of the benefits of implementing this type of technology in Chile is that we have enormous ENCS resources of all kinds (solar, wind, geothermal, hydroelectric and tidal power), but they are intermittent, so the use of hydrogen would be highly convenient. 

The researchers say that this project “is not targeted at large companies for now, but remote places, like small settlements or fishing villages away from interconnected grid systems, little mine sites and road construction zones, etc.”

They expect to fully implement the project by mid-2016. Although they acknowledge that it is necessary to make this technology more price competitive, they say that costs have significantly fallen in recent times due to the huge development of fuel cell vehicles.

Translated by Marcela Contreras

• Dr Erick Saavedra Flores, researcher at the Department of Civil Works Engineering of Universidad de Santiago de Chile, is studying new mathematical techniques to computer simulate the performance of wood at extreme ranges of deformation, cracking and ductile processes and its possible progressive collapse.

Wooden structures in a seismic country like Chile require constant inspection to check on its resistance in case of critical events such as earthquakes.

Dr Erick Saavedra Flores, researcher at the Department of Civil Works Engineering of Universidad de Santiago de Chile, is studying new mathematical techniques to computer simulate the performance of wood at extreme ranges of deformation, cracking and ductile processes and, eventually, in a progressive collapse.

Dr Saavedra explains that failures in wooden structures are divided into two groups: brittle and ductile failures. Both will determine the time before wood collapses. “Usually, structures fail abruptly, without previous notice. This type of failure is classified as ‘brittle’. However, at a local level, close to metal joints or fittings, wood fails in a “ductile” manner, i.e., it fails gradually in time. This latter type of failure is very common in very high buildings made of wood,” he says.

With the resources provided by a Fondecyt Regular project, Dr Saavedra will present a new model based on a mathematical technique called “homogenization”, which seeks to detect cracking and irreversible deformation processes at different spatial scales.

Worldwide efforts

“Achieving this goal will be a big challenge, because we require to extend the existing theory to incorporate the damage factor, i.e., degradation, loss of material stiffness and cracks into the multi-scale mechanical response of the material. In the past few years, big efforts have been made worldwide; however, predicting the mechanical performance of materials in this context remains to be a problem without a solution that is fully accepted by the scientific community,” he says.

He explains that he intends to incorporate this new material model to the advanced analysis of large-scale structures, because the big challenge posed by this goal is to computer simulate the progressive collapse of structures during seismic events.

In this regard, modeling this problem is extremely difficult as it involves extreme deformation processes, the interaction of elements that fall during the collapse process and their consequent fragmentation.

The project also considers experimental testing to validate the numerical predictions obtained during the study. Running these tests will be possible with the acquisition of a vibrating table for the Department of Civil Works Engineering.

As a final result of this study, the researcher expects to have material advanced models able to capture extreme deformation processes that allow to calculate ductility measures.

“I believe that the major impact my project may have is in the area of design and construction of buildings and large-scale structures. In the case of wood, particularly, it is possible to promote the use of radiata pine to construct tall buildings if we have a more precise knowledge of its performance during failures or eventual structural collapse,” Dr Saavedra explains. 

The study will be conducted in the context of the Fondecyt Regular project 2016 (1160691), “Advanced Modelling of Ductility and Damage in Mass Timber Structures by Computational Homogenization.”

Translated by Marcela Contreras

• With the funding of a Fondecyt Postdoctoral Project 2016, Dr Baptiste Darbois, professor at the Faculty of Science of Universidad de Santiago, will be able to accurately determine how lizards move in granular soils in order to produce results that allow to create a robot able to move easily in different types of soil.

With the funding of a Fondecyt Postdoctoral Project 2016, Dr Baptiste Darbois, professor at the Faculty of Science of Universidad de Santiago, will be able to accurately determine how lizards move in granular soils in order to produce results that allow to create a robot able to move easily in different types of soil. This would mean a significant contribution to robotics.

Based on previous research that found that once lizards dive in the sand, they move by wriggling their bodies and not by using their legs, Dr Darbois will study the interaction between a vibrating elastic structure and the granular environment.

The Fondecyt Postdoctoral project (3160167) is called “Locomoción ondulatoria de nadadores suaves dentro de los medios granulares.”

Experimental challenge

The experimental challenge of the study is to control the movement of grains and the forces they undergo when lizards move. This would help to establish guidelines for developing robots able to adapt themselves to different environments. The way of moving of different animals has inspired engineers in this field.

“We expect the compression produced by lizards’ undulating movements in the desert’s sub-surface to help us to develop efficient robots by incorporating this mechanism,” Dr Darbois explained.

Likewise, professor Darbois intends to develop, in the long term, a robot based on the best features lizards show when moving in a granular environment.

“Through this project, we expect to define the optimal conditions: the dimensions, elasticity, frequency and amplitude of vibrations to move forward in waves through a granular environment,” the researcher said.

The relationship between lizards and the development of robots is not odd; on the contrary, it can benefit technological development and improve people´s quality of life. For example, it can be used in critical situations.

“With regard to its applications, developing robots able to efficiently move in granular environments could help to detect anti-personnel mines in the deserts and find people trapped under avalanches,” Dr Darbois concluded.

Translated by Marcela Contreras