• His paper deals with details about how a person's exposure to carbon dioxide affects cerebral blood flow. The information was provided by experimental British patients, as part of a collaborative work with the University of Leicester.

Dr. Max Chacón, professor at the Department of Informatics Engineering, Faculty of Engineering, was awarded the 2011 Jack Perkins Prize by the Institute of Physics and Engineering in Medicine (IPEM) of England, for his publication "Non-linear multivariate modelling Hemodynamics of cerebral hemodynamics with Autoregressive Support Vector Machines.”

 The award, which consists of  £ 250, is given annually to the best paper published during the year in the Medical Engineering & Physics journal, after a review carried out by a specialized committee that evaluates aspects such as the novelty and impact of the research.

 Dr. Chacon thanked the award and noted that this type of survey research confirms the good work being done in this University. "This is an important recognition for us, especially because our paper in the area of cerebral self regulation did not belong to the field of biomechanics, the journal’s strongest line of research, which could have been  the most possible winner”, he said.

The winner added that "all the profits for this recognition are indirect: for example, increasing the bonds of cooperation not only with the university we work with (Leicester), but also with other foreign institutions".

Significant contribution to medicine

The awarded paper is part of a specific area called cerebral hemodynamics. Professor Chacón  is working with two other researchers: Claudio Araya, former student of Master’s degree at the U. of Santiago, and Ronney Panerai from the University of Leicester (England).

 The cerebral hemodynamics acquires vital importance, because the estimates of international organizations involved in the field of health in Chile indicate that by 2025 more people will die from brain strokes than heart attacks. It is believed that the blood flow would be strongly linked to vascular accidents and also with a number of diseases, such as Alzheimer's, arteriosclerosis (carotid artery, mainly), head trauma, vascular dementia and diabetes, among others.

"Cerebral strokes are rising very strongly in the country and the causes are unknown. One thing that causes brain damage is the stronger flow in the arteries. It is known that the brain has a flow control system, and this means that, although the pressure varies in the body, the flow is almost constant in the brain. If there is little flow, one loses consciousness and, conversely, if there is a lot of flow an artery breakdown happens, “Chacón explained.

This mechanism, which constantly generates blood flow into the brain, is what researchers try to model through a data–based nonlinear system. This publication addresses one of the topics related to cerebral hemodynamics, because of the data given by the English researcher who provided the information based on 16 healthy patients who breathe in air with a small fraction (5%) of carbon dioxide (CO2) through a mask. The aim was to know how breathing in this gas affects the regulation of the blood flow in the brain.

"We proved that it is possible to represent changes in the inhalation of CO2 in a person by using this nonlinear model and this has metabolic implications, for instance. We know that breathing in a fraction of CO2 produces changes, which are equivalent to those experienced by people with diabetes, i.e. a metabolic problem, and these problems affect the blood flow in the same way as CO2 does it, “the researcher said.

Prize

The IPEM is an institution dedicated to joining professionals from the physical sciences, clinical engineering, the academic world, the health services and the industry, in order to share knowledge and advances in science and technology. Since 2000, it gives the Jack Perkins Prize in honor of his first journal’s editor, who died in 2000.

• The renowned Journal of Coordination Chemistry dedicated its issue 67 to Dr. Juan Costamagna, academic at the Faculty of Chemistry and Biology of Universidad de Santiago, for his contribution to the development of this journal since 2000, when he was invited to be part of the Editorial Board. The journal aims at disseminating the investigations of renowned researchers in the field of Chemistry of Coordination Compounds in countries like the United States, France, Argentina, South Africa, and Chile, among others. 

In recognition of his significant contributions to the development of the Journal of Coordination Chemistry and in the context of his retirement from the Editorial Board, the journal dedicated a special issue to Dr. Juan Costamagna, researcher at the Faculty of Chemistry and Biology of Universidad de Santiago.

The journal aims at disseminating the investigations of renowned researchers in the field of Chemistry of Coordination Compounds in countries like the United States, France, Argentina, Uruguay, South Africa, Spain, Italy, Mexico, and Chile.

Jim Atwood, who was in charge of issue 67 called “Special Issue: To honor Professor Juan Costamagna on the occasion of his retirement", highlighted in the opening pages professor Costamagna’s “valuable opinion” and his contribution over the years “with his expertise” to the development of this publication.

Atwood pointed out that Dr. Costamagna “has been a consummate collaborator and has brought his talent to the Editorial Board of this Journal; he has published over 100 papers in the field of Coordination Chemistry and has served 14 times as the Chilean delegate to the International Advisory Committee of the International Conference on Coordination Chemistry between 1974 and 2006. He was also an Advisor to the Nobel Prize of Chemistry from 1996 to 2000”. This is the background for this special issue available since December on http://www.tandfonline.com/toc/gcoo20/67/23-24.
 

Contribution to Science

The participation of Dr. Costamagna in the journal dates back to 2000, when he was appointed to the Editorial Board by the journal’s general editor.

Since then, Dr. Costamagna has contributed with countless academic evaluations and several plenary “Online Annual Meetings” of the Editorial Board. The journal has positioned itself as a model in the field of Chemistry of Coordination Compounds. “I think I have modestly contributed to this growth and development,” Dr. Costamagna said.

Regarding his plans in the editorial work, Dr. Costamagna said that he will continue working as emeritus editor for “Communications in Inorganic Synthesis”, an online journal sponsored by Universidad de Santiago.


Translated by Marcela Contreras

• Researchers at Universidad de Santiago, in partnership with researchers at the University of California (USA), developed a software program that includes several applications to study reading comprehension in users of digital texts. They will analyze the reading tracks in students and professionals all over the country to understand the cognitive processes developed when approaching a text on screen.

New technologies have also had an impact on people’s reading habits, as a result of the widespread use of digital texts. However, according to different studies, this change has not improved reading comprehension in Chilean people.  Thus, researchers at Universidad de Santiago have developed a software program that includes several applications to study reading comprehension in users of this type of text.

“Reading comprehension is essential to any field of knowledge. If someone does not have a good reading comprehension level, it will be more difficult for him/her to understand science, mathematics and texts related to financial products or a contract, for example. For this reason, we designed computerized environments for users to develop information processing strategies that allow them to process this information in a way that eases their understanding,” Dr Héctor Ponce, professor at the Department of Accounting and Auditing and an expert in information systems, said.

To design these environments, Dr Ponce and other professors at Universidad de Santiago have developed several software applications to improve reading comprehension of digital texts by including information processing strategies, like note-taking, cause-effect diagrams, sequences and comparisons. These strategies were turned into applications that complement each other, proving the effectiveness of this technology.

The results encouraged researchers to conduct further research on how Chilean people read and understand. They are currently working on the Regular Fondecyt Project (1151092) “Facilitation of cognitive processes by means of different computer-aided information processing strategies: An eye movement analysis.”

“Although we process information in different ways, there area some repeated patterns that we are trying to identify through this study. This why we will asses the cognitive strategies that a person uses when reading,” the researcher explained.

“For this purpose, we will use a computer-connected device called ‘eye-tracker’. It detects where on the screen the user is looking at, it follows the eye movement and detects how long someone spends watching objective elements, like words, for example, or the eye movement track when processing a text, among other aspects,” he added.

To inquire into how strategies help in understanding a text, tests will be run with plain texts without strategies, and with other texts that involve individual and multiple strategies.

The research team includes experts in cognitive psychology, like Dr Verónica Figueroa, co-investigator and researcher at Universidad de Santiago, and Dr Richard Mayer, professor at the University of California (Santa Barbara), who is collaborating in the study.

The project implementation started in March this year and it will involve school and university students and professionals. The study is divided in three phases: first, the design of the material to be used; then, testing and data collection through the eye-tracking device; and finally, the analysis of the collected data.

According to Dr Ponce, the results of the study could have two potential impacts. One is the software improvement, as the most effective strategies could be assembled to understand what is being read. And the other, the possibility of improving the content presentation in textbooks and the presentation of specialized information, like the one related to online products sales, health care plans, and contracts, among others.

“In a society, it is very important for people to be able to understand what they read, as one of the natural consequences of a good comprehension is a better decision-making,” Dr Ponce stressed.

Translated by Marcela Contreras

·         The amount awarded will be supplemented by institutional funds, through the Vice Presidency of Research, Development and Innovation. This will allow the Faculty of Chemistry and Biology to renovate and acquire new equipment for the important research work that they develop.

Universidad de Santiago was awarded 571 million 528 thousand Chilean pesos in the IV Scientific and Technology Equipment Fund (Fondequip) Grant Contest. Fondequip is a program led by the National Commission for Scientific and Technological Research (Conicyt).

The funds will benefit different research projects.

Dr Raúl Cordero, professor at the Department of Physics of Universidad de Santiago is leading the project “Characterization of Clouds in the Antarctic Peninsula and the Southern Ocean” that seeks to better understand the interrelation between clouds and polar climate.

“Through interactions with short wave and long wave radiation, clouds significantly impact the energy balance, contributing to warming (or cooling) the Earth surface. The clouds are the biggest source of uncertainty in global climate models and affect the forecast of future climate scenarios,” the researcher said.

Therefore, in a context of climate change, “a better understanding of the clouds over the Southern Ocean and the Antarctic Peninsula is urgent,” the researcher said.

Thanks to the funds awarded, Dr Cordero will be able to acquire a Micro Pulse LIDAR (MPL), a high- tech remote sensing laser system that provides constant and independent follow-up of clouds profiles and properties. The equipment will be assembled on Universidad de Santiago’s Research Platform (62º 12’ S; 58º 57’ W), on San Jorge Island, located in the Austral Ocean, to the north of the Antarctica Peninsula.

To guarantee the access and dissemination of the measurements and data generated by the new equipment, it will be connected to the NASA’s “Micro Pulse Lidar Network” (MPLNET).

Confocal microscope

The Faculty of Chemistry and Biology was also granted funds for two projects. One of them is led by Dr Claudio Acuña Castillo, head of the Department of Biology. According to the researcher, they seek to “renovate the confocal microscope to keep our competitiveness and increase the number of papers published by the areas of Biology and Biomedicine.”

The third initiative that received funding was the project for updating and acquiring new accessories for a nuclear magnetic resonance spectrometer that will strengthen different research areas in chemistry. Dr Juan Guerrero of the Faculty of Chemistry and Biology is leading this project.

Impact of new equipment

According to Dr Raúl Cordero, “by means of the acquisition of cutting edge technology, this contest allows Chile to strengthen the scientific instrumentation of the Universidad de Santiago’s Antarctic Platform and contributes to training advanced human capital, at an undergraduate and graduate levels, with an specialization both in the polar atmosphere and climate change.”

For his part, Dr Acuña says that having this type of funds available allow us to have the leading-edge equipment required to generate competitive research.

Translated by Marcela Contreras

• In order to develop more tolerable therapies, a research team at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile studies the use of biodegradable nanoparticles to increase the Adenosine Triphosphate (ATP) circulation time in the body to combat cancer.

In order to develop more tolerable therapies, a research team at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile studies the use of biodegradable nanoparticles to increase the Adenosine Triphosphate (ATP) circulation time in the body to combat cancer.

The study is led by Dr Patricia Díaz, professor at the Faculty of Chemistry and Biology and is being developed in the context of the 2016 Fondecyt Post Doc Project (3160837) "Uso de nanopartículas con circulación prolongada para la administración de ATP en tratamientos anticancerígenos." Dr Díaz and her team will test new nanotechnology-based applications to deliver cancer-fighting drugs into the body.

She explains that any drug delivered in the body for therapeutic purposes requires a circulation time to play its therapeutic role.

Some molecules, like ATP, are quickly degraded, so high constant drug doses are required to be therapeutically effective and this is not beneficial for patients.

“As drugs are encapsulated in nanoparticles, the enzymes that metabolize them cannot bind to them. This is why they are protected against degradation. Consequently, drugs’ half-life is increased, prolonging its therapeutic efficacy,” she explains. 

Improved treatments

The advantage of using ATP as a cancer-fighting drug is that it has minor side effects if compared to other drugs. But ATP degrades very quickly when it is recognized by the enzymes in the body. Therefore, different drug administration methods are required, like the use of nanoparticles with biodegradable and biocompatible properties.

“For this reason, we want to encapsulate ATP into biocompatible nanoparticles to increase its half-life. We will also use other strategies to make them invisible to the immune system, so that they can circulate longer. The idea is to prevent them from binding to the cell and to avoid extracellular release of ATP. In this way, we expect to have a higher amount of drug available in the body for a prolonged anti-cancer effect,” she explains.

According to Dr Díaz, the main objective of the study is to test the effectiveness of ATP-carrying nanoparticles in cancer treatment. “I expect to demonstrate that nanoparticle-encapsulated drugs increase their bioavailability when compared with conventional administration methods. Besides, we also expect to analyze the potential synergistic effect of administrating ATP in combination with other drugs frequently used in cancer treatment.”

“This synergistic effect could destroy a higher number of cancer cells, benefiting patients with advanced cancer,” she adds.

Another advantage of this type of treatment is that, as it allows a sustained release of drugs in time, patients could receive the treatment once a week or every two or more weeks, depending on the drug encapsulation capacity and its circulation time,” she concludes. 

Dr Juan Pablo García-Huidobro, researcher at the Faculty of Chemistry and Biology, is also participating in the study, which is being conducted at the Pharmacology Laboratory.

Translated by Marcela Contreras

• These researchers seek to change the concept of nutrition through an artificial intelligence startup, which has also developed other 100% plant-based products with the same taste, texture and smell as traditional foods.

• By means of a Regular Fondecyt Project, researchers at the Faculty of Chemistry and Biology, led by Dr. Brenda Modak, are studying a treatment to protect the national salmon farming industry from the dangerous bacterium Piscirickettsia Salmonis, by using wild plants from the Atacama Desert.
• “Synthetic products have proved to be a problem where they have been used as they accumulate at the bottom of the sea. This is the reason why we refer to this as a sanitary challenge that national aquaculture has to face. Working with a natural compound will not only lead to a less invasive cure: there will also be less pollution in waters where it is used,” Dr. Modak stressed.

In the last decades, aquaculture in Chile has been constantly growing, placing Chile in the first place of producers in America, according to the Food and Agriculture Organization of the United Nations (FAO). Also, salmon production accounts for 76% of the national fish farming industry, according to the National Service of Fishing. For these reasons, infections affecting salmon farming at a national level can become a serious problem for the country.

“We are the world’s second leading country in salmon farming, after Norway. So, everything related to infectious diseases becomes important, even more, when it comes to Piscirickettsia salmonis, a bacterium that has killed about 50% of the salmon population in the country,” affecting an industry that generates more than 60 thousand jobs in the south of the country,” Dr. Brenda Modak stressed.

In order to find effective solutions to this problem, Dr. Modak, together with a multidisciplinary research team from Universidad de Santiago’s Faculty of Chemistry and Biology, are working on the Regular Fondecyt Project “Evaluation of natural products with potential antibacterial activity against P. Salmonis.”

“We are trying to test the activity of natural products isolated from plants against this bacterium (P. Salmonis), which has been difficult to combat with common synthetic antibiotics. However, our compounds have proved to be effective as antiviral drugs and immunostimulants for salmons, so this is where the idea of testing them in salmons already infected came from,” she said.

To develop the treatment, researchers will work with plants that grow wildly in the Atacama Desert, which produce a resin that covers the plants to protect themselves against the unfavorable environment in which they grow.

“We will extract the resin from the plant and then we will separate its different components. We have seen that the resin is made of two groups of compounds, from which we will take some samples and test them against the bacterium,” she said.

Three Universidad de Santiago’s laboratories are taking part in this study: the Laboratory of Chemistry of Natural Products, the Laboratory of Immunology and the Laboratory of Virology. First, the study of the extracted resin will be started until the pure compounds are obtained. This will be followed by the bacterial cell growth. Then, the in vitro work will be done, observing how the bacterium is affected by the compounds. Finally, in the in vivo work, salmons will be infected and then they will be given an injection with the elaborated product.

“Synthetic products have proved to be a problem where they have been used as they accumulate at the bottom of the sea. This is the reason why we refer to this as a sanitary challenge that national aquaculture has to face. Working with a natural compound will not only lead to a less invasive cure: there will also be less pollution in waters where it is used,” Dr. Modak stressed.
 

Translated by Marcela Contreras

• The project, led by Dr. Ricardo Salazar, professor at the Faculty of Chemistry and Biology of the University, aims at decontaminating the water from dyes waste and additives, by using electricity and solar energy.

The textile industry in Chile was born in the mid-nineteenth century and expanded thanks to the measures of protection of the internal market which were implemented at that time. Another factor was the arrival of Palestinian immigrants that gave prosperity to the development of the industry.

However, as all industrial activity, this industry was also a contaminant, due to the use of water in its tasks.

This situation becomes a serious problem when you consider that our country has  supply and drought problems. In this context, Dr. Ricardo Salazar, an academic at the Faculty of Chemistry and Biology at the U. Santiago, is leading the Fondecyt project: "Degradation of dyes in wastewater from the textile industry by electrochemical oxidation technologies.” With this project, he aims to provide a solution for wastewater reuse in this process.

The study comes from a previous work by this expert that consisted in analyzing water decontamination of pesticides used in the wine industry. "The first two projects involved water treatment in the laboratory and comprised a chemical study. Now, however, I proposed the construction of a pilot plant to treat more wastewater from the textile industry”, Salazar said.

The project aims to be a contribution to environmental conflict resolution. This is the vital motivation for this academic, who seeks to decontaminate waters that contain dyes wastes and additives. To achieve this, he will work with electricity and solar energy and without using chemicals.

In addition, Dr. Salazar adds that "laws are becoming more stringent for industries in terms of technology demand and waste disposal rates. Therefore, the industries will have to be prepared. The idea is to step forward and provide an approach to this conflict and be useful in the future. "

Purification Process

The purification process is performed by the hydroxyl radical, which derives from water oxidation. This element reacts with the organic components present in the water, degrades pollutants and transforms the contaminant organic compounds into carbon dioxide.

Some of the steps included in this four-year project are: to finish the work in the laboratory, which aims to observe what happens in the whole process; identify each of the compounds that are produced and, finally, build a pilot plant. In this last stage, the scholar has the direct support of Dr. Julio Romero, project co-investigator who is also a researcher at the Faculty of Engineering of the University.

For Dr. Salazar, the importance of the research that he develops lies, mainly, on the human capital formation and in the "responsibility of changing the image of research in the country. Our work could contribute to the enterprise, the industry and, obviously, the University, as we could get the latest technological equipment to develop the project and internationalize the name of the institution. "

By Marcela González

• “Broccoli’s myrosinase enzyme production and encapsulation for its use as a food supplement” That is the name of the Fondef project recently awarded to Alejandro Angulo, a graduate of Universidad de Santiago. In the VIU line (Valorización de la Investigación en la Universidad, in Spanish), the funds will allow to develop a capsule to prevent different cancers.

It is well known that eating vegetables provides many health benefits; even more: some of them have disease preventive properties. Like broccoli, for example, that according to different studies, can be a natural anticancer agent.

Based on this idea, Alejandro Angulo, Biotechnology Engineer graduated from Universidad de Santiago, submitted the project “Broccoli’s myrosinase enzyme production and encapsulation for its use as a food supplement” to the IV VIU Contest of Fondef (Fund for the Promotion of Scientific and Technological Development) and he was recently awarded the funds. The initiative has the purpose of developing a capsule to enhance the natural ability of the broccoli to prevent different cancers.

Alejandro Angulo, director of the project, explains that this vegetable is able to produce some antioxidant and anticancer compounds called isothiocyanates, like sulforphane, that is highly powerful. The precursor to this compound, the myrosinase enzyme, is found in broccoli. When you chew it, its tissue breaks down, the enzyme and the substrate react and sulforphane is naturally released. “If we have more optimal or high-activity enzymes, we could maximize the content of these anticancer compounds,” the researcher said.

For the above, he proposes to create a capsule containing purified enzyme that, when eaten with broccoli, increases the sulforphane content in the body, and therefore, its anticancer effect. However, the researcher warns that the product “would allow preventing cancer, but it would not be a treatment for cancer.”

The researcher says that the idea of developing this food supplement arose when he was looking for a topic for his dissertation work and contacted Dr. Andrea Mahn. She was working on a Fondecyt project that sought to transform broccoli into a functional food. “I focused on the broccoli enzyme that acts as a catalyst for the chemical reaction that releases the anticancer compound, and aspect that she was not studying. In my dissertation work I was trying to describe this enzyme to then purify it and leave it ready to be used in the product. It was then when we thought of developing a food supplement,” he remembers.

His idea was one of the 12 proposals submitted by Universidad de Santiago that won the last VIU Contest version, a historical record that ranks our University in the first place this year. The study will have the support of the Department of Technology Transfer (DGT, in Spanish) to move forward to the ultimate goal: to develop the product for market.

The project is at its first stage that includes a business plan and a work plan; then it will be evaluated to continue to the second stage: the project implementation. “In the long term, we expect to meet all the project stages and position the product as a recognized brand. The idea is to position the brand and sell our product,” the researcher concluded.

Translated by Marcela Contreras

• A new index is the result of the study conducted by a research team at the Department of Informatics Engineering of Universidad de Santiago, led by Dr Max Chacón. This may be a great contribution to improve early detection and measurement of neurodegenerative diseases, like amyothrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease and other alterations in cerebral hemodynamics, including cerebrovascular accidents, and subarachnoid hemorrhages, among others.

Cerebral autoregulation is a mechanism which aims to maintain stable cerebral blood flow, despite of the changes in blood pressure.

In order to measure this mechanism, the Aaslid Tiecks method is widely used, but it is not accurate and sometimes it provides false positives that make difficult to differentiate between healthy and sick subjects.

During the study conducted by academics of our University in partnership with the Department of Cardiovascular Sciences at the University of Leicester (United Kingdom), when the new model was applied to 16 healthy men, promising results were observed. 

This new index uses two parameters that are obtained directly from the response signal of the brain to a decrease in arterial blood pressure caused by the sudden release of bilateral thigh cuffs, and a third parameter that measures the difference between the gradient of this response and the change in arterial blood pressure.

“This new index means an improvement in the whole system. The former index did not allow differentiating between healthy and sick individuals in a correct way. When you see the results of the tests, there is an improvement in the evaluation of healthy subjects. The next challenge is to test the index in pathological cases, to confirm the results already obtained,” Dr Chacón said.

University support

Professor Chacón stressed that the study was “completely conducted at the university.” He also highlighted the support that they received from Universidad de Santiago, as the study was brought forth thanks to the contribution of the Department of Scientific and Technological Research and the Department of Informatics Engineering.

Besides, professor Chacón expressed his gratitude to his work team, made up of Dr José Luis Lara, co-author of the study and professor at the Department of Informatics Engineering, and Dr Ronney Panerai, also co-author of this work and professor at the University of Leicester. The researcher also thanked Dr Gonzalo Acuña and Dr Millaray Curilem, both professors at Universidad de la Frontera, who did not formally take part in the study, but contributed to make this research a reality.

Publication of paper

The study results were published in the paper ‘A new model-free index on dynamic cerebral blood flow autoregulation’, where the new index is proposed. It represents a breakthrough in medicine.

The paper was also published by Plos one, one of the most important scientific journals around the world. According to Dr Chacón, this journal is one of the fastest means to publish, so it provides a way to disseminate the results of his work.

He explained that his work “should have a big impact because it is a useful tool at the service of medicine. As it is useful and shows concrete results, the paper might be cited in several occasions.”

Translated by Marcela Contreras